Serious neutropenia in ALL patients treated with L-asparaginase may be avoided by therapeutic monitoring of the enzyme activity in the circulation

Therapeutic Drug Monitoring

Volumn 24, Issue 4, 2002, Pages 502-506

  Ylikangas, Päivi ^a   Mononen, Ilkka ^a  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Acute lymphoblastic leukemia; Glycosylasparaginase; L asparaginase

Indexed keywords

ASPARAGINASE; DOXORUBICIN; METHOTREXATE; N4 (BETA N ACETYLGLUCOSAMINYL)ASPARAGINASE; PREDNISOLONE; PREDNISONE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; AREA UNDER THE CURVE; ARTICLE; CANCER REGRESSION; CHILD; CIRCULATION; CLINICAL ARTICLE; DRUG BLOOD LEVEL; DRUG MONITORING; ENZYME ACTIVITY; HIGH RISK PATIENT; HUMAN; NEUTROPENIA; PRIORITY JOURNAL;

ADOLESCENT; ANTINEOPLASTIC AGENTS; AREA UNDER CURVE; ASPARAGINASE; CHILD; CHILD, PRESCHOOL; DRUG MONITORING; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; NEUTROPENIA;

EID: 0036337935     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200208000-00007     Document Type: Article

References (11)

1. L-asparaginase and PEG asparaginase - Past, present and future
2. Asparaginase: Where do we go from here?
3. Monitoring of asparaginase activity and asparagine levels in children on different asparaginase preparations
4. Unexpected mortality from the use of E. coli L-asparaginase during remission induction therapy for childhood acute lymphoblastic leukemia: A report from the Taiwan Pediatric Oncology Group
5. Influence of two different E. coli asparaginase preparations on coagulation and fibrinolysis: A randomized trial
6. A Fluorometric assay for L-asparaginase activity and monitoring of L-asparaginase therapy
7. Childhood cancer in the Nordic countries. Report on epidemiologic and therapeutic results from registries and workshops
8. Effects of the antifungal agents on oxidative drug metabolism: Clinical relevance