A gain-of-function mutation in the second tetratricopeptide repeat of TFIIIC131 relieves autoinhibition of Brf1 binding

Molecular and Cellular Biology

Volumn 22, Issue 17, 2002, Pages 6131-6141

  Moir, Robyn D ^a   Puglia, Karen V ^a   Willis, Ian M ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED RNA POLYMERASE III; PROTEIN SUBUNIT; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BRF1; TRANSCRIPTION FACTOR IIIB; TRANSCRIPTION FACTOR IIIC; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; GENE; GENE MUTATION; LIGAND BINDING; NONHUMAN; PCF1 GENE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; DNA, FUNGAL; GENES, DOMINANT; LIGANDS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; REPETITIVE SEQUENCES, AMINO ACID; RNA POLYMERASE III; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTOR TFIIIB; TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS, TFIII;

EID: 0036337439     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.17.6131-6141.2002     Document Type: Article

References (42)

1. Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20
2. Two components of Saccharomyces cerevisiae transcription factor IIIB (TFIIIB) are stereospecifically located upstream of a tRNA gene and interact with the second-largest subunit of TFIIIC
3. Complex interactions between yeast TFIIIB and TFIIIC
4. Kinetic trapping of DNA by transcription factor IIIB
5. The structure of the tetratricopeptide repeats of protein phosphatase 5: Implications for TPR-mediated protein-protein interactions
6. Interaction between yeast RNA polymerase III and transcription factor TFIIIC via ABC10α and τ131 subunits
7. Multiple roles of the τ131 subunit of yeast transcription factor IIIC (TFIIIC) in TFIIIB assembly
8. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit
9. Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5
10. The RNA polymerase III transcription apparatus
11. The RNA polymerase III-recruiting factor TFIIIB induces a DNA bend between the TATA box and the transcriptional start site
12. SWISS-MODEL and the Swiss-Pdb-Viewer: An environment for comparative protein modeling
13. Comparison of the RNA polymerase III transcription machinery in Schizosaccharomyces pombe, Saccharomyces cerevisiae and human
14. A cryptic DNA binding domain at the COOH terminus of TFIIIB70 affects formation, stability, and function of preinitiation complexes
15. Essential roles of Bdp1, a subunit of RNA polymerase III initiation factor TFIIIB, in transcription and tRNA processing
16. Alternative outcomes in assembly of promoter complexes: The roles of TBP and a flexible linker in placing TFIIIB on tRNA genes
17. Identification of amino acids in the tetratricopeptide repeat and C-terminal domains of protein phosphatase 5 involved in autoinhibition and lipid activation
18. Two essential components of the Saccharomyces cerevisiae transcription factor TFIIIB: Transcription and DNA-binding properties
19. S. cerevisiae TFIIIB is the transcription initiation factor proper of RNA polymerase III, while TFIIIA and TFIIIC are assembly factors
20. The role of the TATA-binding protein in the assembly and function of the multisubunit yeast RNA polymerase III transcription factor, TFIIIB
21. Functional and structural organization of Brf, the TFIIB-related component of the RNA polymerase III transcription initiation complex
22. The RNA polymerase III transcription initiation factor TFIIIB participates in two steps of promoter opening
23. Transcription factor IIIB generates extended DNA interactions in RNA polymerase III transcription complexes on tRNA genes
24. Conserved functional domains of the RNA polymerase III general transcription factor BRF
25. Functional dissection of the B″ component of RNA polymerase III transcription factor IIIB: A scaffolding protein with multiple roles in assembly and initiation of transcription
26. Structure of the TPR domain of p67phox in complex with Rac.GTP
27. Saccharomyces cerevisiae transcription factors IIIB and IIIC bend the DNA of a tRNA(Gln) gene
28. Expression and purification of the RNA polymerase III transcription specificity factor IIIB70 from Saccharomyces cerevisiae and its cooperative binding with TATA-binding protein
29. PCF4 encodes an RNA polymerase III transcription factor with homology to TFIIB
30. The TFIIIB-assembling subunit of yeast transcription factor TFIIIC has both tetratricopeptide repeats and basic helix-loop-helix motifs
31. Interactions between the tetratricopeptide repeat-containing transcription factor TFIIIC131 and its ligand, TFIIIB70. Evidence for a conformational change in the complex
32. Autoinhibition of TFIIIB70 binding by the tetratricopeptide repeat-containing subunit of TFIIIC
33. A tetratricopeptide repeat mutation in yeast transcription factor IILC131 (TFIIIC131) facilitates recruitment of TFIIB-related factor TFIIIB70
34. Spatial organization of the core region of yeast TFIIIB-DNA complexes
35. A mutation in the second largest subunit of TFIIIC increases a rate-limiting step in transcription by RNA polymerase III
36. A suppressor of mutations in the class III transcription system encodes a component of yeast TFIIIB
37. Structure of TPR domain-peptide complexes: Critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine
38. A differential response of wild type and mutant promoters to TFIIIB70 overexpression in vivo and in vitro
39. Two structures of cyclophilin 40, folding and fidelity in the tpr domains
40. The PCF1-1 mutation increases the activity of the transcription factor (TF) IIIB fraction from Saccharomyces cerevisiae
41. A selection for mutants of the RNA polymerase III transcription apparatus: PCF1 stimulates transcription of tRNA and 5S RNA genes