Vascular responses in vivo to 8-epi PGF2α in normal and hypercholesterolemic pigs

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 283, Issue 2 52-2, 2002, Pages

  Krier, James D ^a   Rodriguez Porcel, Martin ^b   Best, Patricia J M ^c   Carlos Romero, J ^c   Lerman, Amir ^b   Lerman, Lilach O ^a,c  

^a Divisions of Hypertension ^*  (United States)

^b Cardiovascular Diseases   (United States)

^c MAYO CLINIC   (United States)

Author keywords

Glomerular filtration rate; Hypercholesterolemia

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 8 ISOPROSTAGLANDIN F2 ALPHA; ISOPROSTANE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL INJURY; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DISEASE MARKER; FEMALE; GLOMERULUS FILTRATION RATE; HYPERCHOLESTEROLEMIA; HYPERTENSION; KIDNEY CORTEX; KIDNEY FUNCTION; KIDNEY MEDULLA; KIDNEY PERFUSION; MEAN ARTERIAL PRESSURE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SWINE;

EID: 0036333665     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00602.2001     Document Type: Article

References (43)

1. Role of thromboxane in impaired renal vasodilatation response to acetylcholine in hypercholesterolemic rats
2. 2α: An index for oxidative injury via free radical catalysed lipid peroxidation
3. Coronary endothelial function is preserved with chronic endothelin receptor antagonism in experimental hypercholesterolemia in vitro
4. Determination of plasma isoprostanes by enzyme immunoassay in pigs. A reliable and sensitive assay
5. Thromboxane A2 and prostaglandin endoperoxide analogue effects on porcine renal blood flow
6. In vivo formation of 8-Epi-prostaglandin F2α is increased in hypercholesterolemia
7. 2α and platelet activation in diabetes mellitus: Effects of improved metabolic control and vitamin E supplementation
8. In vivo renal vascular and tubular function in experimental hypercholesterolemia
9. 8-Iso-PGF2α induces β2-integrin-mediated rapid adhesion of human polymorphonuclear neutrophils: A link between oxidative stress and ischemia/reperfusion injury
10. Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells
11. Oxidized low density lipoproteins potentiate vasoconstrictions to various agonists by direct interaction with vascular smooth muscle
12. Low-dose angiotensin II increases free isoprostane levels in plasma
13. Augmented responses to vasoconstrictor stimuli in hypercholesterolemic and atherosclerotic monkeys
14. A reliable and sensitive enzyme immunoassay method for measuring 8-isoprostaglandin F2α: A marker for lipid peroxidation after experimental brain injury
15. Angioplasty increases coronary sinus F2-isoprostane formation: Evidence for in vivo oxidative stress during PTCA
16. Generation of 8-epi-prostaglandin F(2α) in isolated rat kidney glomeruli by a radical-independent mechanism
17. Noninvasive measurement of concurrent, single-kidney perfusion, glomerular filtration, and tubular function
18. Coronary artery constriction by the isoprostane 8-epi prostaglandin F2α
19. Prostaglandin F2α (PGF2α) and the isoprostane, 8,12-iso-isoprostane F2α-III, induce cardiomyocyte hypertrophy. Differential activation of downstream signaling pathways
20. The isoprostane 8-iso-PGF2a stimulates endothelial cells to bind monocytes: Difference to thromboxane-mediated endothelial activation
21. Increased oxidative stress in experimental renovascular hypertension
22. Plasma, urinary, and salivary 8-epi-prostaglandin f2α levels in normotensive and preeclamptic pregnancies
23. F(2)-isoprostanes mediate high glucose-induced TGF-β synthesis and glomerular proteinuria in experimental type I diabetes
24. Formation of F2-isoprostanes during oxidation of human low density lipoprotein and plasma by peroxynitrite
25. Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage
26. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism
27. Portal levels of the isoprostane F2α-III, a marker of lipid peroxidation, do not correlate with increased portal pressure in cirrhotic patients
28. Local amplification of platelet function by 8-Epi prostaglandin F2α is not mediated by thromboxane receptor isoforms
29. Increased formation of distinct F2 isoprostanes in hypercholesterolemia
30. Isoprostanes. Novel markers of endogenous lipid peroxidation and potential mediators of oxidant injury
31. Measurement of F(2)-isoprostanes unveils profound oxidative stress in aged rats
32. Combination of hypercholesterolemia and hypertension augments renal function abnormalities
33. Hypercholesterolemia impairs myocardial perfusion and permeability: Role of oxidative stress and endogenous scavenging activity
34. Physiological and pathophysiological roles of oxygen radicals in the renal microvasculature
35. 2 and NO
36. Impaired renal vascular endothelial function in vitro in experimental hypercholesterolemia
37. Renal vascular function in experimental hypercholesterolemia is preserved by chronic antioxidant vitamin supplementation
38. Glomerular actions of a free radical-generated novel prostaglandin, 8-epi-prostaglandin F2α, in the rat. Evidence for interaction with thromboxane A2 receptors
39. Effects of 8-epiprostaglandin F2α and U46,619 on pulmonary hemodynamics in piglets
40. 2 receptor expression and TGF response to U-46,619
41. Potentiation of tubuloglomerular feedback in the rat by thromboxane mimetic. Role of macula densa
42. Simvastatin preserves coronary endothelial function in hypercholesterolemia in the absence of lipid lowering
43. Enhanced coronary vasoconstriction to oxidative stress product, 8-epi-prostaglandin F2a, in experimental hypercholesterolemia