Optimizing hematopoietic stem cell engraftment: A novel role for thrombopoietin

Journal of Clinical Investigation

Volumn 110, Issue 3, 2002, Pages 303-304

  Verfaillie, Catherine M ^a,b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLT3 LIGAND; GRANULOCYTE COLONY STIMULATING FACTOR; PROTEIN TYROSINE KINASE; THROMBOPOIETIN;

AUTOTRANSPLANTATION; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL DIVISION; CELL INTERACTION; CELL LINEAGE; CELL SURVIVAL; GENE MUTATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MESENCHYME; MOLECULAR CLONING; NEUTROPHIL; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0036330421     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0216376     Document Type: Note

References (16)

1. Previously undetected human hematopoietic cell populations with short-term repopulating activity, selectively engraft NOD/SCID-beta2 microglobulin-null mice
2. Long-term lymphohematopoietic reconstitution by a single 34-low/negative hematopoietic stem cell
3. The murine W/c-kit and Steel loci and the control of hematopoiesis
4. Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor
5. Studies of W mutant mice provide evidence for alternate mechanisms capable of activating hematopoietic stem cells
6. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors
7. Mice lacking flt3 lig- and have deficient hematopoiesis affecting hemaropoietic progenitor cells, dendritic cells, and natural killer cells
8. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mp1 ligand thrombopoietin
9. Thrombopoietin and the c-Mp1 receptor: Insights from gene targeting
10. Ability of early acting cytokines to directly promote survival and suppress apoptosis of human primitive CD34+CD38-bone marrow cells with multilineage potential at the single-cell level: Key role of thrombopoietin
11. c-mp1 mutations are the cause of congenital amegakaryocytic thrombocytopenia
12. Thrombopoietin expands hematopoietic stem cells after transplantation
13. Mp1 ligand prevents lethal myelosuppression by inhibiting p53-dependent apoprosis
14. Regulation of rhrombopoietin levels by c-mp1-mediated binding to platelets
15. Granulocyte colony-stimulating factor after allogeneic bone marrow transplantation
16. Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor