Interferon-alpha (Intron A) upregulates urokinase-type plasminogen activator receptor gene expression

Cancer Immunology, Immunotherapy

Volumn 51, Issue 5, 2002, Pages 248-254

  Wu, Shanshan ^a   Murrell, George A ^b   Wang, Yao ^a  

^a Biology and Environment   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Colon cancer cell; Gene expression; Interferon (IFN); Urokinase type plasminogen activator receptor (uPAR)

Indexed keywords

ALPHA INTERFERON; AMILORIDE; BUTYRIC ACID; CYCLOHEXIMIDE; GAMMA INTERFERON; MESSENGER RNA; RECOMBINANT ALPHA2B INTERFERON; UROKINASE RECEPTOR;

ARTICLE; CANCER CELL; CELL STIMULATION; COLON CANCER; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN SYNTHESIS; RECEPTOR UPREGULATION;

AMILORIDE; CYCLOHEXIMIDE; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTERFERON TYPE II; INTERFERON-ALPHA; PROTEIN SYNTHESIS INHIBITORS; RECEPTORS, CELL SURFACE; RNA, MESSENGER; SODIUM OXYBATE; TIME FACTORS; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0036329094     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-002-0275-5     Document Type: Article

References (32)

1. uPA, uPAR, PAI-1: Key intersection of proteolytic, adhesive and chemotactic highways?
2. Molecular and biologic characterization of recombinant interferon-alpha 2b
3. Determination of the levels of urokinase and its receptor in human colon carcinoma cell lines
4. Determination of the effects of epidermal growth factor on urokinase secretion and urokinase receptor display in a well-differentiated human colon carcinoma cell line
5. Examination of the effects of epidermal growth factor on the production of urokinase and the expression of the plasminogen activator receptor in a human colon cancer cell line
6. Initiation and characterisation of cultures of human colonic carcinoma with different biological characteristics utilising feeder layers of confluent fibroblasts
7. Sodium butyrate inhibits expression of urokinase and its receptor mRNAs at both transcription and post- transcription levels in colon cancer cells
8. A region between -141 and -61 bp containing a proximal AP-1 is essential for constitutive expression of urokinase-type plasminogen activator receptor
9. Plasminogen activation initiated by single-chain urokinase-type plasminogen activator: Potentiation by U937 cells
10. Inhibition of receptor-bound urokinase by plasminogen-activator inhibitors
11. Escape from negative regulation of growth by transforming growth factor beta and from the induction of apoptosis by the dietary agent sodium butyrate may be important in colorectal carcinogenesis
12. Lysosomal degradation of receptor-bound urokinase-type plasminogen activator is enhanced by its inhibitors in human trophoblastic choriocarcinoma cells
13. Antimetastatic effect of amiloride in an animal tumor model
14. IFN-γ, tumour necrosis factor-α, and urokinase regulate the expression of urokinase receptors on human monocytes
15. Two alternatively spliced mouse urokinase receptor mRNAs with different histological localisation in the gastrointestinal tract
16. Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences
17. Urokinase-receptor biosynthesis, mRNA level and gene transcription are increased by transforming growth factor 1 in human A549 lung carcinoma cells
18. Human 18S ribosomal RNA sequence inferred from DNA sequence. Variations in 18S sequence and secondary modification patterns between vertebrates
19. Interferons and retinoids enhance and dexamethasone suppresses urokinase-mediated plasminogen activation in promyelocytic leukemia cells
20. r receptor protein for urokinase-type plasminogen activator
21. The plasminogen system and cell surfaces: Evidence for plasminogen and urokinase receptors on the same cell type
22. Cloning and expression of the receptor for urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis
23. + exchange for tumor growth
24. A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation
25. Cytokine-specific regulation of urokinase receptor (CD87) expression by U937 mononuclear phagocytes
26. Regulation of c-myc expression by sodium butyrate in the colon carcinoma cell line Caco-2
27. Amiloride selectively inhibits the urokinase-type plasminogen activator
28. Human urokinase receptor expression is inhibited by amiloride and induced by tumor necrosis factor and phorbol ester in colon cancer cells
29. Structure of the human urokinase receptor gene and its homology to CD59 and the Ly-6 family
30. Identification of a novel nuclear factor-kappa B sequence involved in expression of urokinase-type plasminogen activator receptor
31. The role and regulation of urokinase-type plasminogen activator receptor gene expression in cancer invasion and metastasis