Identification of metabolites of a substance P (Neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma

Drug Metabolism and Disposition

Volumn 30, Issue 8, 2002, Pages 937-943

  Hop, Cornelis E C A ^a,b   Wang, Yanfeng ^a,b   Kumar, Sanjeev ^a,b   Elipe, Maria Victoria Silva ^a,b   Raab, Conrad E ^a,b   Dean, Dennis C ^a,b   Poon, Grace K ^a,b   Keohane, Carol Ann ^a,b   Strauss, John ^a,b   Chiu, Shuet Hing L ^a,b   Curtis, Neil ^a,b   Elliott, Jason ^a,b   Gerhard, Ute ^a,b   Locker, Karen ^a,b   Morrison, Denise ^a,b   Mortishire Smith, Russell ^a,b   Thomas, Steven ^a,b   Watt, Alan P ^a,b   Evans, David C ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 CYCLOPROPYLOXY 5 TRIFLUOROMETHOXYPHENYL) 6 PHENYL 1 OXA 7 AZASPIRO[4.5]DECANE; DRUG METABOLITE; LACTAM; NEUROKININ 1 RECEPTOR ANTAGONIST; NITRONE; OXOACID; PIPERIDINE; SUBSTANCE P ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEAMINATION; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG STRUCTURE; LIQUID CHROMATOGRAPHY; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY;

ADMINISTRATION, ORAL; ANIMALS; AZA COMPOUNDS; CHROMATOGRAPHY, LIQUID; HEPATOCYTES; INJECTIONS, INTRAVENOUS; KETO ACIDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROKININ-1; SPIRO COMPOUNDS; SUBSTANCE P;

ANIMALIA; EMESIS;

EID: 0036320875     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.8.937     Document Type: Article

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