Clinical and gene mutation studies on a Chinese pedigree with glucocorticoid-remediable aldosteronism

Chinese Medical Journal

Volumn 115, Issue 7, 2002, Pages 979-982

  Ding, Wei ^a   Liu, Libin ^a   Hu, Renming ^a   Xu, Manyin ^a   Chen, Jialun ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Aldosterone; Aldosteronism; Fusion gene; Glucocorticoid; Renin

Indexed keywords

ALDOSTERONE; ALDOSTERONE SYNTHASE; DEXAMETHASONE; GLUCOCORTICOID; HYDROCORTISONE; MINERALOCORTICOID; POTASSIUM; RENIN; STEROID 11BETA MONOOXYGENASE;

ADENOMA; ADOLESCENT; ADULT; ARTICLE; BIOCHEMISTRY; BLOOD LEVEL; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; CHILD; CHINESE; CLINICAL FEATURE; CLINICAL STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSSING OVER; DNA SEQUENCE; FEMALE; FUSION GENE; GENE MUTATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HYPERALDOSTERONISM; HYPERTENSION; HYPOKALEMIA; IDIOPATHIC DISEASE; INTRON; MAJOR CLINICAL STUDY; MALE; MOLECULAR MECHANICS; PATHOGENESIS; PEDIGREE; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; TREATMENT OUTCOME; URINE LEVEL;

ADRENOCORTICOTROPIC HORMONE; ADULT; ALDOSTERONE; FEMALE; GLUCOCORTICOIDS; HUMANS; HYPERALDOSTERONISM; MUTATION; PEDIGREE;

EID: 0036316269     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Hypertension, increased aldosterone secretion, and low renin activity relieved by dexamethasone
2. Glucocorticoid-remediable aldosteronism (GRA): Diagnosis, variability of phenotype and regulation of potassium homeostasis
3. Glucocorticoid-suppressible hyperaldosteronism, a case report
4. Glucocorticoid-remediable aldosteronism in a large kindred: Clinical spectrum and diagnosis using a characteristic biochemical phenotype
5. A clinical study on primary aldosteronism
6. Transient fall and subsequent return of high aldosteronic secretion by adrenal adenoma during continued dexamethasone administration
7. A new genetic test for familial hyperaldosteronism type 1 aids in the detection of curable hypertension
8. A chimaeric 11-beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension
9. Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase
10. Glucocorticoid-suppressible hyperaldosteronism: Effects of crossover site and parental origin of chimaeric gene on phenotypic expression
11. Pathophysiology of deoxycorticosterone-secreting adrenal tumors