Phototoxic effect of fluoroquinolones on two human cell lines

Toxicology in Vitro

Volumn 16, Issue 4, 2002, Pages 449-456

  Trisciuoglio, D ^a   Krasnowska, E ^b   Maggi, A ^a   Pozzi, R ^a   Parasassi, T ^b   Sapora, O ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b CNR   (Italy)

Author keywords

Cytotoxicity; Fluoroquinolones; In vitro toxicity; Membrane damage; Oxidative damage; Photosensitization

Indexed keywords

FLUOROQUINOLONE OFLOXACIN; LAURDAN; MEMBRANE LIPID; QUINOLONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; OFLOXACIN;

BIOASSAY; CELL COUNT; CELL MEMBRANE; CELL MEMBRANE DEPOLARIZATION; CELL STRAIN HL 60; CELL STRAIN K 562; CELL SURVIVAL; CLONING; CONFERENCE PAPER; CONTROLLED STUDY; CYTOLYSIS; DRUG WITHDRAWAL; FLUORESCENCE; HUMAN; HUMAN CELL; INCUBATION TIME; IRRADIATION; LETHALITY; LIPID OXIDATION; LIPID PEROXIDATION; PHOTOSENSITIZATION; PHOTOTOXICITY; RADIATION DOSE; TOXICITY TESTING; ARTICLE; CELL DEATH; DRUG EFFECT; ERYTHROCYTE; OXIDATIVE STRESS; PATHOLOGY; PHOTOSENSITIVITY DISORDER; ULTRAVIOLET RADIATION;

ANTI-INFECTIVE AGENTS, FLUOROQUINOLONE; CELL DEATH; CELL MEMBRANE; ERYTHROCYTES; HL-60 CELLS; HUMAN; LIPID PEROXIDATION; OFLOXACIN; OXIDATIVE STRESS; PHOTOSENSITIVITY DISORDERS; ULTRAVIOLET RAYS; ANTI-INFECTIVE AGENTS; HUMANS;

EID: 0036314165     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(02)00029-2     Document Type: Conference Paper

References (31)

1. Mutagenicity and carcinogenicity of topoisomerase interactive agents
2. Influence of solvent polarity and proticity on the photochemical properties of norfloxacin
3. Radiation chemical and physical mechanisms of radiosensitization of single cell systems by iothalammate
4. Induction of morphological and functional differentiation of human promyelocytic leukemia cells (HL60) by compounds which induce differentiation of murine leukemia cells
5. Reactive oxygen species in tissue injury
6. Fluoroquinolone photosensitization: A review of clinical and laboratory studies
7. In vitro phototoxic activities of the new quinolone antibacterial agents: Lipid peroxidative potentials
8. Quantitative assay for mutation in diploid human lymphoblasts using microtiter plates
9. Human cell membrane oxidative damage induced by single and fractionated doses of ionizing radiation: A fluorescence spectroscopy study
10. Fluoroquinolone antimicrobial agents
11. Photoallergic reaction caused by enoxacin
12. K562 and HL60 membrane aging during cell growth is associated with changes in cholesterol concentration
13. Singlet oxygen and superoxide yields do not correlate with fluoroquinolone phototoxicity
14. Photogeneration of fluoride by fluoroquinolone antimicrobial agents lomefloxacin and fleroxacin
15. Role of lipid structure in the activation of Phospholipase A2 by peroxidized phospholipids
16. Oxidant-mediated activation of phospholipases C and D
17. Radiation sensitizers in ultra-violet irradiation of cellular systems
18. Lysosomes are sites of fluoroquinolone photosensitization in human skin fibroblasts: A microspectrofluorimetric approach
19. Membrane aging during cell growth ascertained by Laurdan generalized polarization
20. Evidence for an increase in water concentration in bilayer after oxidative damage of phospholipids induced by ionizing radiation
21. Membrane oxidative damage induced by ionizing radiation detected by diphenylexatriene lifetime distributions
22. Alterations on erythrocyte membrane lipids induced by low doses of ionizing radiation as revealed by 1,6-diphenyl-1,3,5-hexatriene fluorescence lifetime
23. Adverse drug reactions with fluoroquinolone
24. K562, a human cellular system capable to undergo in vitro differentiation: Measurement of genotoxic parameters useful for cytotoxicity evaluation
25. Impairment of phagocytic cells respiratory burst by UVA in the presence of fluorochinolones: An oxygen dependent phototoxic damage to cell surface microvilli
26. Signalling mechanisms and oxidative stress in apoptosis
27. Molecular mechanisms of photosensititation XI: Membrane damage and DNA cleavage photo-induced by enoxacin
28. Important role of oxygen metabolites in quinolone antibacterial agent-induced cutaneous phototoxicity in mice
29. Possible direct role of reactive oxygens in the cause of cutaneous phototoxicity induced by five quinolones in mice
30. Photosensitivity associated with antibacterial agents