Somatic mutations in the p53 gene account for the extension of replicative life span of macaque cells

Biochemical and Biophysical Research Communications

Volumn 295, Issue 3, 2002, Pages 644-650

  Shimizu, Yuko ^a   Ishida, Takafumi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Cellular aging; M1; M2; Macaques; p53

Indexed keywords

AMINO ACID; NUCLEOTIDE; PROTEIN P53;

ANIMAL CELL; ARTICLE; CELL AGING; CELL STRAIN; CELL SURVIVAL; CHROMOSOME; CONTROLLED STUDY; GENE DELETION; GENE SILENCING; HETEROZYGOSITY LOSS; MACACA; MISSENSE MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; SOMATIC MUTATION; STOP CODON;

ANIMALS; BASE SEQUENCE; CHROMOSOMES; DNA, COMPLEMENTARY; GENES, P53; HAPLOTYPES; HETEROZYGOTE; MACACA; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTATION; MUTATION, MISSENSE; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID;

MACACA; MACACA FASCICULARIS; MACACA FUSCATA;

EID: 0036314076     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00730-1     Document Type: Article

References (13)

1. Reversible cellular senescence: Implications for immortalization of normal human diploid fibroblasts
2. Escape from senescence in human diploid fibroblasts induced directly by mutant p53
3. Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: Aneuploidy and immortalization
4. INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts
5. Progress of aging in human diploid cells transformed with a tsA mutant of simian virus 40
6. Sequence of a cDNA encoding the p53 protein in Rhesus monkey (Macaca mulatta)
7. Regulation of p53 function
8. Database of p53 gene somatic mutations in human tumors and cell lines
9. Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
10. Single-site methylation within the p53 promoter region reduces gene expression in a reporter gene construct: Possible in vivo relevance during tumorigenesis
11. p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts
12. Telomere maintenance mechanisms and cellular immortalization