Cationic interactions at the human dopamine transporter reveal binding conformations for dopamine distinguishable from those for the cocaine analog 2α-carbomethoxy-3α-(4-fluorophenyl)tropane

Journal of Neurochemistry

Volumn 81, Issue 6, 2002, Pages 1383-1393

  Chen, Nianhang ^a,b,c   Sun, Lingling ^a   Reith, Maarten E A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b NANJING MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Binding; Cation; Cocaine analog; Dopamine transporter; Protein conformation

Indexed keywords

2ALPHA CARBOMETHOXY 3ALPHA (4 FLUOROPHENYL)TROPANE; ASPARAGINE; ASPARTIC ACID; CATION; COCAINE DERIVATIVE; DOPAMINE; DOPAMINE TRANSPORTER; LEUCINE; LITHIUM ION; MUTANT PROTEIN; POTASSIUM ION; PROTON; SODIUM ION; TROPANE DERIVATIVE; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CATION TRANSPORT; COCAINE DEPENDENCE; CONTROLLED STUDY; DOPAMINERGIC TRANSMISSION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; GENE MUTATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; PH; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN INTERACTION; SODIUM TRANSPORT; STRUCTURE ACTIVITY RELATION; TRANSPORT KINETICS;

BINDING, COMPETITIVE; CATIONS; CELL LINE; COCAINE; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DRUG INTERACTIONS; HUMANS; LITHIUM; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT MODULATORS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; POTASSIUM; PROTONS; SODIUM;

EID: 0036312480     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.00941.x     Document Type: Article

References (33)

1. + dependence of the neuronal transport of dopamine
2. Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter
3. Which form of dopamine is the substrate for the human dopamine transporter: The cationic or the uncharged species?
4. 3H]mazindol
5. Studies of voltage-sensitive sodium channels using ligand binding methods
6. 125I]iodophenyl) tropane-2 α-carboxylic acid isopropyl ester to the dopamine transporter
7. Transport-dependent accessibility of a cytoplasmic loop cysteine in the human dopamine transporter
8. Mutation of tryptophan 84 or aspartate 313 enhances sodium/proton interactions with human dopamine transporter leading to high-affinity binding of a cocaine analogue an inefficient transport of dopamine
9. Cationic modulation of human dopamine transporter: Dopamine uptake and inhibition of uptake
10. The role of conserved tryptophan and acidic residues in the human dopamine transporter as characterized by site-directed mutagenesis
11. 50) of an enzymatic reaction
12. Binding of uptake blockers to the neuronal dopamine transporter: Further investigation about cationic and anionic requirements
13. Evidence for the sequential formation of two complexes between an uptake inhibitor, GBR 12783[1-[2-(diphenylmethoxy) ethyl]-4-(3-phenyl-2-propenyl) piperazine] and the neuronal transporter of dopamine
14. Multisubtrate mechanism for the inward transport of dopamine by the human dopamine transporter expressed in HEK cells and its inhibition by cocaine
15. Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter
16. Mutation of K448 in the external loop 5 of rat GABA transporter rGAT1 induces pH sensitivity and alters substrate interactions
17. + and methanethiosulfonate reagents
18. + required for the binding of dopamine, amphetamine, tyramine, and octopamine to the human dopamine transporter?
19. 3H]WIN 35,428 to the human dopamine transporter
20. - with the binding of amphetamine, octopamine, and tyramine to the human dopamine transporter
21. An intermediate state of the gamma-aminobutyric acid transporter GAT1 revealed by simultaneous voltage clamp and fluorescence
22. Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains
23. + and glucose transport
24. Structural studies of the melibiose permease of Escherichia coli by fluorescence energy transfer
25. Ion binding and permeation at the GABA transporter GAT1
26. A multisubstrate mechanism of striatal dopamine uptake and its inhibition by cocaine
27. A lithium-induced conformational change in serotonin transporter alters cocaine binding, ion conductance, and reactivity of cys-109
28. Ionic interactions in the Drosophila serotonin transporter identify it as a serotonin channel
29. 3H]tropane to the dopamine uptake carrier
30. The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporter
31. Ion dependence of neurotransmitter uptake: Inhibitory effects of ion substitutes
32. Multiple ionic conductances of the human dopamine transporter: The actions of dopamine and psychostimulants
33. Modeling of the pH dependence of the binding of WIN 35,428 to the dopamine transporter in rat striatal membranes: Is the bioactive form positively charged or neutral?