Diol- and triol-type ginseng saponins potentiate the apoptosis of NIH3T3 cells exposed to methyl methanesulfonate

Toxicology and Applied Pharmacology

Volumn 181, Issue 3, 2002, Pages 192-202

  Hwang, Sung Jin ^a   Cha, Jae Young ^a   Park, Seh Geun ^a   Joe, Gi Jung ^a   Kim, Hyung Min ^a   Moon, Hyung Bae ^a   Jeong, Se Jin ^a   Lee, Jung Sup ^a   Shin, Dong Hwa ^a   Ko, Sung Ryong ^a   Park, Jong Kun ^a  

^a Wonkwang University   (South Korea)

Author keywords

Apoptosis; CDK2; Ginseng saponin; MMS; P53; PD; PT

Indexed keywords

ACRIDINE ORANGE; CELL CYCLE PROTEIN; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN E; CYCLINE; GINSENG SAPONIN; MESYLIC ACID METHYL ESTER; PROTEIN P21; PROTEIN P53; TRYPAN BLUE;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL POPULATION; CELL ULTRASTRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; FIBROBLAST; FLUORESCENCE ACTIVATED CELL SORTING; MOUSE; NONHUMAN; PROTEIN EXPRESSION; WESTERN BLOTTING;

PANAX GINSENG;

EID: 0036311253     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2002.9413     Document Type: Article

References (63)

1. p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts
2. Review: How to activate p53
3. Chk2/hCds1 functions as a DNA damage checkpoint in G (1) by stabilizing p53
4. Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA
5. Ginsenoside Rg1 down-regulates glucocorticoid receptor and displays synergistic effects with cAMP
6. Thymocyte apoptosis induced by p53-dependent and independent pathways
7. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
8. WAF1, a potential mediator of p53 tumor suppression
9. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis
10. Review: The p53 pathway and cancer therapy
11. Bcl-2 delay of alkylating agent-induced apoptotic death in a murine hemopoietic stem cell line
12. p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents
13. Ras-related GTPase RhoB forces alkylation-induced apoptotic cell death
14. 2+ and Ras signaling pathways
15. Specificity of mutations induced by methyl methanesulfonate in mismatch repair-deficient human cancer cell lines
16. Review: Cytotoxic and cytostatic effects of antitumor agents induced at the plasma membrane level
17. Biological response to phorbol ester determined by alternative G1 pathways
18. Influence of some DNA-alkylating drugs on thermal stability, acid and osmotic resistance of the membrane of whole human erythrocytes and their ghosts
19. Membrane cell permeabilisation with saponin and multiparametric analysis by flow cytometry
20. Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53
21. Participation of p53 protein in the cellular response to DNA damage
22. Ginsenoside-Rs3, a new diol-type ginseng saponin, selectively elevates protein levels of p53 and p21WAF1 leading to induction of apoptosis in SK-HEP-1 cells
23. Ginsenoside-Rs4, a new type of ginseng saponin concurrently induces apoptosis and selectively elevates protein levels of p53 and p21WAF1 in human hepatoma SK-HEP-1 cells
24. Chemical studies of crude drugs. (1) Constituents of ginseng radix rubra
25. c-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents
26. Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cells
27. Wild-type p53 is a cell cycle checkpoint determinant following irradiation
28. Loss of cell adhesion to substratum up-regulates p21cip1/WAF1 expression in BALB/c 3T3 fibroblasts
29. Effect of ultraviolet light, methyl methanesulfonate and ionizing radiation on the genotoxic response and apoptosis of mouse fibroblasts lacking c-Fos, p53 or both
30. Primary mouse fibroblasts deficient for c-Fos, p53 or for both proteins are hypersensitive to UV light and alkylating agent-induced chromosomal breakage and apoptosis
31. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
32. Ginsenoside-Rg5 suppresses cyclin E-dependent protein kinase activity via up-regulating p21 cip/WAF1 and down-regulating cyclin E in SK-HEP-1 cells
33. Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome c-mediated activation of caspase-3 protease
34. Ginsenoside-Rg1, one of the major active molecules from panax ginseng, is a functional ligand of glucocorticoid receptor
35. Specific interaction between tetrandrine and Quillaja saponins in promoting perme-abilization of plasma membrane in human leukemic HL-60 cells
36. Differential effects by the p21 CDK inhibitor on PCNA dependent DNA replication and repair
37. Transcriptional activation of the CDK inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937
38. Anti-proliferative effect of ginseng saponins on human prostate cancer cell line
39. p53 is required for radiation-induced apoptosis in mouse thymocytes
40. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells
41. p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs
42. Regulation of CD95 (APO-1/Fas) receptor and ligand expression by lipopolysaccharide and dexamethasone in parenchymal and nonparenchymal rat liver cells
43. Review: Cellular responses to DNA damage
44. 6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent
45. Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes
46. Plant-glycoside modulation of cell surface related to control of differentiation in cultured B16 melanoma cells
47. Induction by ionizing radiation of the gadd45 gene in cultured human cells: Lack of mediation by protein kinase C
48. Glucocorticoid receptor-induced down-regulation of MMP-9 by ginseng components, PD and PT contributes to inhibition of the invasive capacity of HT1080 human fibrosarcoma cells
49. The mdm-2 gene is induced in response to UV light in a p53-dependent manner
50. Review: The p53 pathway
51. 2+ channel currents in rat sensory neurons
52. The effect of methyl methanesulfonate (MMS)-induced excision repair on p53-dependent apoptosis in human lymphoid cells
53. Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2
54. Review: The cellular response to p53: The decision between life and death
55. p53-mediated DNA repair responses to UV radiation: Studies of mouse cells lacking p53, p21 and/or gadd45 genes
56. Epithelial cells of different organs exhibit distinct patterns of p53-dependent and p53-independent apoptosis following DNA insult
57. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
58. An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells
59. A case-control study of ginseng intake and cancer
60. Preventive effect of ginseng intake against various human cancer: A case-control study on 1987 pairs
61. Induction of cellular p53 activity by DNA-damaging agents and growth arrest
62. p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation
63. A role for p53 in base excision repair