Tritium labelling and characterization of the antimalarial drug (+/-)-chloroquine by several methods

Applied Radiation and Isotopes

Volumn 57, Issue 3, 2002, Pages 343-345

  Egan, Judith A ^a   Laseter, Anne G ^a   Filer, Crist N ^a  

^a PERKINELMER INC   (United States)

Author keywords

(+ ) Chloroquine; Tritium; Tritium NMR

Indexed keywords

ALKYLATION; CATALYSIS; DEHALOGENATION; DRUG PRODUCTS;

ANTIMALARIAL ACTION;

TRITIUM;

ANTIMALARIAL AGENT; CHLOROQUINE; DEETHYLCHLOROQUINE; TRITIUM;

ALKYLATION; ANTIMALARIAL ACTIVITY; ARTICLE; CATALYSIS; DEHALOGENATION; DRUG MECHANISM; ISOTOPE LABELING; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

ANTIMALARIALS; CHLOROQUINE; DRUG DESIGN; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; STEREOISOMERISM; TRITIUM;

EID: 0036311216     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8043(02)00117-3     Document Type: Article

References (8)

1. A convenient short synthesis of desethylchloroquine
2. A study on the electrophilic iodination of chloroquine
3. 3H] pyronaridine by Plasmodium falciparum-infected erythrocytes in vitro
4. 3H] strychnine at high specific activity
5. 3H] clonidine hydrochloride at high specific activity
6. 4-Aminoquinolines - Past, present and future: A chemical perspective
7. On the molecular mechanism of chloroquine's antimalarial action
8. Synthesis, characterization and biological activity of cis-diammineplatinum (II) complexes of the DNA intercalators 9-aminoacridine and chloroquine