Analysis of Spt7 function in the Saccharomyces cerevisiae SAGA coactivator complex

Molecular and Cellular Biology

Volumn 22, Issue 15, 2002, Pages 5367-5379

  Wu, Pei Yun Jenny ^a   Winston, Fred ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; PROTEIN ADA1; PROTEIN SPT20; PROTEIN SPT7; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; DELETION MUTANT; GENETIC TRANSCRIPTION; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN PROCESSING; SACCHAROMYCES CEREVISIAE;

ANTHRANILATE SYNTHASE; BLOTTING, NORTHERN; BLOTTING, WESTERN; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENETIC COMPLEMENTATION TEST; HYDRO-LYASES; INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE; MACROMOLECULAR SUBSTANCES; MULTIENZYME COMPLEXES; MUTAGENESIS, SITE-DIRECTED; PLANT PROTEINS; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036311179     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.15.5367-5379.2002     Document Type: Article

References (47)

1. Role of the Ada2 and Ada3 transcriptional coactivators in histone acetylation
2. A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae
3. Inhibition of TATA-binding protein function by SAGA subunits Spt3 and Spt8 at Gcn4-activated promoters
4. SAGA is an essential in vivo target of the yeast acidic activator Ga14p
5. Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction
6. Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit
7. Tetrahymena histone acetyltransferase A: A homolog to yeast Gcn5p linking histone acetylation to gene activation
8. The Spt components of SAGA facilitate TBP binding to a promoter at a post-activator-binding step in vivo
9. Identification and analysis of yeast nucleosomal histone acetyltransferase complexes
10. SPT3 interacts with TFIID to allow normal transcription in Saccharomyces cerevisiae
11. The Saccharomyces cerevisiae SPT8 gene encodes a very acidic protein that is functionally related to SPT3 and TATA-binding protein
12. Histone folds mediate selective heterodimerization of yeast TAF(II)25 with TFIID components yTAF(II)47 and yTAF(II)65 and with SAGA component ySPT7
13. The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs
14. The Saccharomyces cerevisiae SPT7 gene encodes a very acidic protein important for transcription in vivo
15. Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: Characterization of an Ada complex and the SAGA (Spt/Ada) complex
16. A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation
17. The ATM-related cofactor Tra1 is a component of the purified SAGA complex
18. Targeting of E. coli beta-galactosidase to the nucleus in yeast
19. The bromodomain: A conserved sequence found in human. Drosophila and yeast proteins
20. ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3
21. The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Ga14
22. Redundant roles for the TFIID and SAGA complexes in global transcription
23. Gene disruption with PCR products in Saccharomyces cerevisiae
24. A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID
25. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo
26. Cooperation between complexes that regulate chromatin structure and transcription
27. Histone-like TAFs within the PCAF histone acetylase complex
28. A generic protein purification method for protein complex characterization and proteome exploration
29. Essential functional interactions of SAGA, a Saccharomyces cerevisiae complex of Spt, Ada, and Gcn5 proteins, with the Snf/Swi and Srb/mediator complexes
30. Histone acetyltransferases
31. TOM1p, a yeast hect-domain protein which mediates transcriptional regulation through the ADA/SAGA coactivator complexes
32. Identification of native complexes containing the yeast coactivator/repressor proteins NGG1/ADA3 and ADA2
33. Use of polymerase chain reaction epitope tagging for protein tagging in Saccharomyces cerevisiae
34. Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins
35. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
36. Functional organization of the yeast SAGA complex: Distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction
37. The SANT domain of Ada2 is required for normal acetylation of histones by the yeast SAGA complex
38. SPT5, an essential gene important for normal transcription in Saccharomyces cerevisiae, encodes an acidic nuclear protein with a carboxy-terminal repeat
39. SPT4, SPT5 and SPT6 interactions: Effects on transcription and viability in Saccharomyces cerevisiae
40. A unified nomenclature for TATA box binding protein (TBP)-associated factors (TAFs) involved in RNA polymerase II transcription
41. Transcriptional activators direct histone acetyltransferase complexes to nucleosomes
42. Distribution of acetylated histones resulting from Ga14-VP16 recruitment of SAGA and NuA4 complexes
43. The bromodomain: A chromatin-targeting module?
44. Construction of a set of convenient Saccharomyces cerevisiae strains that are isogenic to S288C
45. Characterization of a human homologue of the Saccharomyces cerevisiae transcription factor spt3 (SUPT3H)