Acute effects of escalating doses of amiodarone in isolated guinea pig hearts

Journal of Veterinary Pharmacology and Therapeutics

Volumn 25, Issue 3, 2002, Pages 221-226

  Bicer, S ^a   Patchell, J S ^a   Hamlin, D M ^a   Hamlin, R L ^a  

^a QTest Laboratories Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; DIMETHYL SULFOXIDE;

ANALYSIS OF VARIANCE; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE CALCULATION; DRUG DETERMINATION; DRUG EFFECT; ELECTROCARDIOGRAM; GUINEA PIG; HEART; HEART BEAT; HEART LEFT VENTRICLE PRESSURE; ISOLATED ORGAN; NONHUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; TIME; UREA CYCLE;

AMIODARONE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; GUINEA PIGS; HEART CONDUCTION SYSTEM; MALE; PERFUSION; RANDOM ALLOCATION;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0036306550     PISSN: 01407783     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2885.2002.00408.x     Document Type: Article

References (22)

1. Pharmacology of amiodarone, an anti-anginal drug with a new biological profile
2. Amiodarone. Biochemical aspects and haemodynamic effects
3. A comparison of the electrophysiologic effects of acute and chronic amiodarone administration on canine Purkinje fibers
4. Efficacy and safety of long-term amiodarone in treatment of cardiac arrhythmias: Dosage experience
5. Amiodarone-associated proarrhythmic effects
6. max of action potential in single ventricular myocytes
7. Electrophysiologic effects of amiodarone: Experimental and clinical observation relative to serum and tissue drug concentrations
8. Effects of long-term oral administration of amiodarone on the ventricular repolarization of rabbit hearts
9. Electrophysiologic effects of desethylamiodarone, an active metabolite of amiodarone: Comparison with amiodarone during chronic administration in rabbits
10. Block of inactivated sodium channels and of depolarization-induced automaticity in guinea pig papillary muscle by amiodarone
11. Intravenous amiodarone in the acute treatment of recurrent symptomatic ventricular tachycardia
12. Frequency-dependent effects of amiodarone on atrioventricular nodal function and slow-channel action potentials: Evidence for calcium channel-blocking activity
13. Cardiac beta-adrenoceptor modulation by amiodarone
14. Adaptation of the QT interval to heart rate changes in isolated perfused guinea pig heart: Influence of amiodarone and D-sotalol
15. Amiodarone. Haemodynamic profile during intravenous administration and effect on pacing-induced ischaemia in man
16. Amiodarone: Individualizing dosage with serum concentrations
17. Amiodarone blocks the inward rectifier potassium channel in isolated guinea pig ventricular cells
18. Amiodarone: Historical development and pharmacologic profile
19. The effects of amiodarone, a new anti-anginal drug, on cardiac muscle
20. Chronic in vivo and in vitro effects of amiodarone on guinea pig hearts
21. Comparison of acute electrophysiological effects of amiodarone and its metabolite desethylamiodarone in Langendorff perfused guinea pig hearts
22. Comparison of the frequency-dependent effects on the atrioventricular node of verapamil, amiodarone, digoxin, and diltiazem in isolated guinea pig hearts