Artificial protein cavities as specific ligand-binding templates: Characterization of an engineered heterocyclic cation-binding site that preserves the evolved specificity of the parent protein

Journal of Molecular Biology

Volumn 315, Issue 4, 2002, Pages 845-857

  Musah, Rabi A ^a   Jensen, Gerard M ^a   Bunte, Steven W ^b   Rosenfeld, Robin J ^a   Goodin, David B ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b U S ARMY RESEARCH LABORATORY   (United States)

Author keywords

Cavity complementation; Cavity mutant; Chemical rescue; Protein engineering; Protein ligand binding

Indexed keywords

2 AMINO 5 METHYLTHIAZOLE; ASPARAGINE; CATION; CYTOCHROME C PEROXIDASE; HYDROGEN; LIGAND; PROLINE; PROTEIN; THIAZOLE DERIVATIVE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; ATOMIC PARTICLE; BINDING AFFINITY; BINDING SITE; CALCULATION; DISSOCIATION CONSTANT; ELECTRICITY; ENERGY; ENTHALPY; ENTROPY; HYDROGEN BOND; HYDROPHOBICITY; LIGAND BINDING; MUTANT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ENGINEERING; PROTEIN INTERACTION; PROTON TRANSPORT; SOLVATION; STRUCTURE ANALYSIS; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

EID: 0036305832     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5287     Document Type: Article

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