HnRNP-A1 binds directly to double-stranded DNA in vitro within a 36 bp sequence

Molecular and Cellular Biochemistry

Volumn 233, Issue 1-2, 2002, Pages 181-185

  Donev, Rossen M ^a   Doneva, Teodora A ^b   Bowen, W Richard ^b   Sheer, Denise ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b SWANSEA UNIVERSITY   (United Kingdom)

Author keywords

Atomic force microscopy (AFM); DNA binding; hnRNP A1; Protein interaction

Indexed keywords

DNA BINDING PROTEIN; DOUBLE STRANDED DNA; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; MESSENGER RNA; RNA; RNA BINDING PROTEIN; SINGLE STRANDED DNA;

ALTERNATIVE RNA SPLICING; ARTICLE; ATOMIC FORCE MICROSCOPY; CHROMOSOME 11Q; CHROMOSOME SIZE; COMPLEX FORMATION; CONTROLLED STUDY; DNA BINDING; DNA SEQUENCE; ELECTROPHORETIC MOBILITY; GENE AMPLIFICATION; GENE TARGETING; GENOME ANALYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; POLYMERASE CHAIN REACTION; PROTEIN DNA BINDING; RNA BINDING; RNA SEQUENCE; RNA TRANSPORT; SEQUENCE ANALYSIS; TELOMERE;

BINDING SITES; CELLS, CULTURED; DNA; DNA PRIMERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FIBROBLASTS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN GROUP A-B; HUMANS; LUNG; MICROSCOPY, ATOMIC FORCE; POLYMERASE CHAIN REACTION; PROTEIN BINDING;

EID: 0036303722     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015504318726     Document Type: Article

References (19)

1. hnRNP proteins and the biogenesis of mRNA
2. Phenyl-alanines that are conserved among several RNA-binding proteins form part of a nucleic acid-binding pocket in the A1 heterogeneous nuclear ribonucleoprotein
3. Recombinant hnRNP protein A1 and its N-terminal domain show preferential affinity for oligodeoxynucleotides homologous to intron/exon acceptor sites
4. Mammalian heterogeneous ribonucleoprotein A1 and its constituent domains. Nucleic acid interaction, structural stability and self-association
5. A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway
6. The roles of heterogeneous nuclear ribonucleoproteins (hnRNP) in RNA metabolism
7. Spatio-temporal expression of the trans-acting splicing factors SF2/ASF and heterogeneous ribonuclear proteins A1/A1B in the myometrium of the pregnant human uterus: A molecular mechanism for regulating regional expression in vivo
8. Heterogeneous nuclear ribonucleoproteins as regulators of gene expression through interactions with the human thymidine kinase promoter
9. Sensitive and rapid method for mapping protein bound to DNA by atomic force microscopy
10. Gene reorganisations and expression of c-ras, c-src, c-mos and c-fos oncogenes in Namalwa, Wish and C6 cells
11. Recombination mediated by vaccinia virus DNA topoisomerase I in Escherichia coli is sequence specific
12. Novel approach to molecular cloning and polynucleotide synthesis using vaccinia DNA topoisomerase
13. Atomic force microscopy of supercoiled DNA structure on mica
14. Artefacts in AFM studies of membranes: Correcting pore images using fast fourier transform filtering
15. A nuclear matrix protein related to intermediate filaments proteins is a member of the complex binding alphoid DNA in vitro
16. RNA binding specificity of hnRNP A1: Significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing
17. Thinking about a nuclear matrix
18. Nuclear matrix-like filaments and fibrogranular complexes form through the rearrangement of specific nuclear ribonucleoproteins
19. Tightly bound matrix DNA probably plays an important role in organisation of chromosome centromeres