Involvement of the skeletal GH-IGF system in an experimental model of diabetes-induced growth retardation

Acta Diabetologica

Volumn 39, Issue 2, 2002, Pages 61-67

  Segev, Y ^a   Landau, D ^a   Davidoff Friedman, S ^a   Weinreb, M ^b   Phillip, M ^a,b  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Diabetes, insulin dependent; Growth; Growth hormone; Growth plate; Insulin like growth factor I

Indexed keywords

GROWTH HORMONE; MESSENGER RNA; SOMATOMEDIN; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; BODY GROWTH; CONTROLLED STUDY; DISEASE ASSOCIATION; EPIPHYSIS; GENE EXPRESSION; GENE LOCATION; GROWTH RETARDATION; IN SITU HYBRIDIZATION; INSULIN DEPENDENT DIABETES MELLITUS; MALE; METAPHYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD; BONE AND BONES; DIABETES MELLITUS, EXPERIMENTAL; GROWTH DISORDERS; GROWTH HORMONE; GROWTH PLATE; INSULIN-LIKE GROWTH FACTOR I; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, IGF TYPE 1; RNA, MESSENGER; SOMATOMEDINS;

EID: 0036303646     PISSN: 09405429     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005920200015     Document Type: Article

References (39)

1. Growth and bone age of juvenile diabetics
2. Growth changes in children and adolescents with short-term diabetes
3. The role of insulin-like growth factor I in growth of diabetic rats
4. Insulin-like growth factors
5. Actions of insulin-like growth factors
6. The regulation of osteoblast function by hormones and cytokines with special reference to insulin-like growth factors and their binding proteins
7. Skeletal growth factor and other growth factors known to be present in bone matrix stimulate proliferation and protein synthesis in human bone cells
8. Primary structure of human skeletal factor homology with human insulin-like growth factor II
9. Skeletal growth factor is produced by human osteoblast-like cells in culture
10. Chemical and biological characterization of low molecular weight human skeletal growth factor
11. Differential expression of insulin-like growth factor-I (IGF-I) and IGF-II messenger ribonucleic acid in growing rat bone
12. Effects of unilateral arterial infusion of GH and IGF-I on tibial longitudinal bone growth in hypophysectomized rats
13. Effect of growth hormone and insulin-like growth factor I (IGF-I) on the expression of IGF-I messenger ribonucleic acid and peptide in rat tibial growth plate and articular chondrocytes in vivo
14. Cellular patterns of IGF system gene expression in murine chondrogenesis and osteogenesis
15. Differential effects of IGF-I and growth hormone on developmental stages of rat growth plate chondrocytes in vivo
16. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
17. Distribution and regulation of rat insulin-like growth factor I mRNA encoding alternative carboxyterminal E peptides: Evidence for differential processing and regulation in liver
18. Developmental regulation of the rat insulin-like growth factor I receptor gene
19. Differential expression of alternative 5′ untranslated regions in mRNA encoding at insulin-like grwoth factor I
20. Differential accumulation of insulin-like growth factor-I in kidneys of pre- and postpubertal streptozotocin-diabetic rats
21. Nucleotide sequence and expression of a cDNA clone encoding a fetal rat binding protein for insulin-like growth factors
22. Structure of the rat insulin-like growth factor binding protein-4 gene
23. Different pattern of alkaline phosphatase, osteopontin and osteocalin expression in developing rat bone visualized by in situ hybridization
24. Expression of the components of the insulin-like growth factor axis across the growth-plate
25. Growth hormone and bone
26. Visual demonstration of growth hormone receptors on human growth plate chondrocytes
27. Insulin-like growth factor-I (IGF-I) and IGF-I receptor (IGF-IR) immunoreactivity in normal and osteopetrotic (toothless, tl/tl) rat tibia
28. Increased energy expenditure in poorly controlled type 1 (insulin-dependent) diabetic patients
29. Differential accumulation of insulin-like growth factor-I in kidneys of pre- and postpubertal streptozotocin-diabetic rats
30. Growth hormone secretory dynamics in streptozotocin diabetes: Evidence of a role for endogenous circulating somatostatin
31. Glomerular hyperfiltration in insulin dependent diabetes mellitus is correlated with enhanced growth hormone secretion
32. Nutrition and somatomedin. XXVI. Molecular regulation of IGF-I by insulin in cultured rat hepatocytes
33. Insulin rapidly decreases IGFBP-1 gene transcription in streptozotocin diabetic rats
34. Phosphorylation of insulin-like growth factor (IGF) binding protein-1 in cell cultures and in vivo: Effects of affinity for IGF-I
35. Glomerulosclerosis in mice transgenic for human insulin-like growth factor-binding protein-1
36. Effect of growth hormone and insulin-like growth factor I (IGF-I) on the expression of IGF-I messenger ribonucleic acid and peptide in rat tibial growth plate and articular chondrocytes in vivo
37. Normal growth and development in the absence of hepatic insulin-like growth factor-I
38. Expression of the genes for IGFs and their receptors in bone during skeletal growth
39. The effects of systemic insulin, insulin-like grwoth factor I and growth hormone on bone growth and turnover in spontaneously diabetic BB rats