Research and development of a second-generation process for bosentan, an endothelin receptor antagonist

Organic Process Research and Development

Volumn 6, Issue 2, 2002, Pages 120-124

  Harrington, Peter J ^a   Khatri, Hiralal N ^a   DeHoff, Brad S ^a   Guinn, Martin R ^a   Boehler, Mark A ^a   Glaser, Karl A ^a  

^a Roche Colorado   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 (2 METHOXYPHENOXY)[2,2' BIPYRIMIDINE] 4,6 DIONE; ACETIC ACID DERIVATIVE; BOSENTAN; DICHLOROMETHANE; ENDOTHELIN RECEPTOR ANTAGONIST; ETHER DERIVATIVE; ETHYLENE GLYCOL; KETONE DERIVATIVE; TOLUENE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; BIOAVAILABILITY; CRYSTALLIZATION; DRUG ISOLATION; DRUG SYNTHESIS; MEDICAL RESEARCH; REDUCTION;

EID: 0036301594     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op010234i     Document Type: Article

References (11)