Amino acid determinants of β-hairpin conformation in erythropoeitin receptor agonist peptides derived from a phage display library

Journal of Molecular Biology

Volumn 316, Issue 5, 2002, Pages 1111-1125

  Skelton, Nicholas J ^a   Russell, Stephen ^a   De Sauvage, Frederic ^a   Cochran, Andrea G ^a  

^a GENENTECH INC   (United States)

Author keywords

Erythropoietin agonists; NMR; Peptide structure; helix; hairpin

Indexed keywords

CYSTEINYLARGINYLALANYLGLYCYLPROLYLLEUCYLGLUTAMINYLTRYPTOPHYLLEUCYLCYSTEINYL GLUTAMYLLYSYLPHENYLALANYLTYROSYLGLYCINE AMIDE; ERYTHROPOIETIN RECEPTOR; ERYTHROPOIETIN RECEPTOR AGONIST; GLYCYLGLYCYLTHREONYLTYROSYLSERYLCYSTEINYLHISTIDYLPHENYLALANYLGLYCYLPROLYLLE UCYLTHREONYLTRYPTOPHYLVALYLCYSTEINYLLYSYLPROLYLGLUTAMINYLGLYCYLGLYCINE AMIDE; PEPTIDE DERIVATIVE; SERYLCYSTEINYLARGINYLALANYLGLYCYLPROLYLLEUCYLGLUTAMINYLTRYPTOPHYLVALYLCYSTE INYLLYSINE AMIDE; SERYLCYSTEINYLHISTIDYLPHENYLALANYLGLYCYLPROLYLLEUCYLGLYCYLTRYPTOPHYLVALYLCY STEINYLLYSINE AMIDE; SERYLCYSTEINYLHISTIDYLPHENYLALANYLGLYCYLPROLYLLEUCYLTHREONYLTRYPTOPHYLVALYL CYSTEINYLLYSINE AMIDE; SOMATOMEDIN BINDING PROTEIN 1; THREONINE; THREONYLTYROSYLSERYLCYSTEINYLHISTIDYLPHENYLALANYLGLYCYLPROLYLLEUCYLGLYCYLTR YPTOPHYLVALYLCYSTEINYLLYSYLPROLYLGLUTAMINE AMIDE; THREONYLTYROSYLSERYLCYSTEINYLHISTIDYLPHENYLALANYLGLYCYLPROLYLLEUCYLTHREONYL TRYPTOPHYLVALYLCYSTEINYLLYSYLPROLYLGLUTAMINE AMIDE; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; CELL PROLIFERATION; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG CONFORMATION; DRUG EFFECT; ISOMERISM; NUCLEAR MAGNETIC RESONANCE; PHAGE DISPLAY; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

EID: 0036300793     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2002.5410     Document Type: Article

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