Engineered improvements in DNA-binding function of the MATa1 homeodomain reveal structural changes involved in combinatorial control

Journal of Molecular Biology

Volumn 316, Issue 2, 2002, Pages 247-256

  Hart, Beverly ^a   Mathias, Jonathan R ^b   Ott, David ^c   McNaughton, Lynn ^a   Anderson, Janet S ^c   Vershon, Andrew K ^b   Baxter, Susan M ^a  

^a WADSWORTH CENTER   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c UNION COLLEGE   (United States)

Author keywords

Combinatorial control; DNA binding affinity; Homeodomain; HSQC; MATa1

Indexed keywords

DNA; DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; MUTANT PROTEIN; PROTEIN; PROTEIN MATA1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CALORIMETRY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIMERIZATION; DNA HELIX; ELECTROPHORETIC MOBILITY; GENE REPRESSION; GENETIC ENGINEERING; MOLECULAR MECHANICS; MOLECULAR RECOGNITION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN VARIANT;

EID: 0036290383     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5333     Document Type: Article

References (29)

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