Detoxification of oxidized LDL by transferring its oxidation product(s) to lecithin:cholesterol acyltransferase

Biochemical and Biophysical Research Communications

Volumn 291, Issue 4, 2002, Pages 758-763

  Howlader, Zakir H ^a   Kamiyama, Shin ^a   Shirakawa, Hitoshi ^a   Murakami, Yohei ^a   Ito, Michiko ^a   Komai, Michio ^a   Muramoto, Koji ^a   Furukawa, Yuji ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Detoxification; HDL; LCAT; Modified LCAT; Oxidized LDL; PL OOH value TBARS value

Indexed keywords

CHOLESTEROL ACYLTRANSFERASE; DYFLOS; HYDROXYAPATITE; LECTIN; LOW DENSITY LIPOPROTEIN; NITROBENZOIC ACID DERIVATIVE; OXIDIZED LOW DENSITY LIPOPROTEIN;

ARTICLE; CHOLESTEROL ESTERIFICATION; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DETOXIFICATION; ENZYME ACTIVITY; ENZYME PURIFICATION; HUMAN; INCUBATION TIME; OXIDATION; PRIORITY JOURNAL;

EID: 0036289659     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2002.6522     Document Type: Article

References (33)

1. High-density lipoprotein metabolism: Molecular targets for new therapies for atherosclerosis
2. Plasma lipoproteins in familial lecithin:cholesterol acyltransferase deficiency: Lipid composition and reactivity in vitro
3. Transgenic rabbits as models for atherosclerosis research
4. The role of oxidized lipoproteins in atherogenesis
5. Oxidatively modified low density lipoproteins: A potential role in recruitment and retention of monocyte/macrophages during atherogenesis
6. Role of lecithin-cholesterol acyltransferase in the metabolism of oxidized phospholipids in plasma: Studies with platelet-activating factor-acetyl hydrolase-deficient plasma
7. Transition metal ions within human atherosclerotic lesions can catalyze the oxidation of low-density lipoprotein by macrophages
8. Endothelial and smooth muscle cells alter low-density lipoprotein in vitro by free radical oxidation
9. Essential role of phospholipase A2 activity in endothelial cell-induced modification of low density lipoprotein
10. Minimally oxidized LDL is a potent inhibitor of lecithin:cholesterol acyltransferase activity
11. Metabolism of oxidized phosphatidylcholines formed in oxidized low-density lipoprotein by lecithin-cholesterol acyltransferase
12. Novel function of lecithin-cholesterol acyltransferase-hydrolysis of oxidized polar phospholipids generated during lipoprotein oxidation
13. Inhibitory effects of oxidized low density lipoprotein on the activity of plasma lecithin:cholesterol acyltransferase
14. Lecithin cholesterol acyltransferase reduces the adverse effects of oxidized LDL while incurring damage itself
15. Oxidation of human low-density lipoprotein results in derivatization of lysine residues of apoli-poprotein B by lipid peroxide decomposition products
16. Lipid peroxides and human diseases
17. Measurement of plasma hydroperoxide concentrations by the ferrous oxidation-xylenol orange assay in conjunction with tri-phenylphosphine
18. Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid
19. Lecithin:cholesterol acyltransferase from human plasma
20. Interaction of rat LCAT with rat apo A-I and with lecithin-cholesterol vesicles
21. Protein measurement with the Folin phenol reagent
22. The interaction of proteins with hydroxyapatite
23. Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions
24. High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein
25. Identification of a domain of lecithin:cholesterol acyltransferase that is involved in interfacial recognition
26. Isolation, properties, and mechanism of in vitro action of lecithin:cholesterol acyltransferase from human plasma
27. Contrasting effects of various sulfhydryl reagents on the activity of lecithin:cholesterol acyltransferase
28. LDL modified by hypochlorous acid is a potent inhibitor of lecithin-cholesterol acyltransferase activity
29. Overexpression of lecithin:cholesterol acyltransferase in transgenic rabbits prevents diet-induced atherosclerosis
30. Molecular physiology of reverse cholesterol transport
31. High-density lipoprotein and lipoprotein oxidation
32. Identification of short-chain oxidized phosphatidylcholine in human plasma
33. Why are low-density lipoproteins atherogenic?