Inhibitory effect of bFgF on endochondral heterotopic ossification

Biochemical and Biophysical Research Communications

Volumn 293, Issue 2, 2002, Pages 680-685

  Sakano, Shinji ^a   Hasegawa, Yukiharu ^a   Murata, Yoshiharu ^b   Ito, Takayasu ^a   Genda, Eiichi ^a   Iwata, Hisashi ^a   Ishiguro, Naoki ^a   Seo, Hisao ^b  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

Author keywords

Basic fibroblast growth factor (bFGF); Bone matrix powder; Endochondral ossification

Indexed keywords

ALKALINE PHOSPHATASE; BASIC FIBROBLAST GROWTH FACTOR; OSTEOCALCIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MATRIX; BONE RADIOGRAPHY; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG EFFECT; ENCHONDRAL OSSIFICATION; HAMSTRING; HETEROTROPHY; IN VIVO STUDY; MALE; MOUSE; MUSCULOSKELETAL DISEASE; NONHUMAN; PRIORITY JOURNAL;

ALKALINE PHOSPHATASE; ANIMALS; BONE AND BONES; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLAST GROWTH FACTOR 2; MALE; MICE; MICE, INBRED C3H; OSSIFICATION, HETEROTOPIC; OSTEOCALCIN; RNA, MESSENGER;

ANIMALIA; MURINAE;

EID: 0036288921     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00273-5     Document Type: Article

References (38)

1. Molecular and biological characterization of fibroblast growth factor, and angi-ogenic factor which also controls the proliferation and differentiation of mesoderm and neuroectoderm derived cells
2. Recombinant human basic fibroblast growth factor accelerates fracture healing by enhancing callus remodeling in experimental dog tibial fracture
3. Potential role of fibroblast growth factor in enhancement of fracture healing
4. Stimulation of fracture repair by recombinant human basic fibroblast growth factor in normal and streptozotocin-diabetic rats
5. Single local injection of recombinant fibroblast growth factor-2 stimulates healing of segmental bone defects in rabbits
6. Local application of basic fibroblast growth factor minipellet induces the healing of segmental bony defects in rabbits
7. Skull bone regeneration in primates in response to basic fibroblast growth factor
8. Fibroblast growth factor is an inhibitor of chondrocyte terminal differentiation
9. Regulation of chondrocyte maturation by fibroblast growth factor-2 and parathyroid hormone
10. In vitro insulin-like growth factor I interaction with cartilage cells derived from postnatal animals
11. Inhibitory effects of basic fibroblast growth factor on chondrocyte differentiation
12. Effects of basic fibroblast growth factor on bone formation in vitro
13. Opposing effects of fibroblast growth factor and pertussis toxin on alkaline phosphatase, osteopontin, osteocalcin, and type I collagen mRNA levels in ROS 17/2.8 cells
14. The interaction of heparin and basic fibroblast growth factor on collagen synthesis in 21-day fetal rat calvariae
15. Basic fibroblast growth factor inhibits type I collagen gene expression in osteoblastic MC3T3-E1 cells
16. Basic fibroblast growth factor destabilizes osteonectin mRNA in osteoblasts
17. Collagen and alkaline phosphatase gene expression during bone morphogenetic protein (BMP)-induced cartilage and bone differentiation
18. Protooncogene expression in osteogenesis induced by bone morphogenetic protein
19. Solubilized bone morphogenetic protein (BMP) from mouse osteosarcoma and rat demineralized bone matrix
20. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
21. Primary structure of rat liver alkaline phosphatase deduced from its cDNA
22. Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones
23. Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone
24. Novel regulators of bone formation: Molecular clones and activities
25. Bone morphogenetic proteins and bFGF exert opposing regulatory effects on PTHrP expression and inorganic pyrophosphate elaboration in immortalized murine endochondral hypertrophic chondrocytes (MCT cells)
26. FGF-4 and BMP-2 have opposite effects on limb growth
27. Morphogenesis of digits in the avian limb is controlled by FGFs, TGFbetas, and noggin through BMP signaling
28. Fibroblast growth factor receptor 3 is a negative regulator of bone growth
29. Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3
30. Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia
31. Mutations in the gene encoding fibroblast growth factor receptor-3 in achon-droplasia
32. FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway
33. Cartilage-derived retinoic acid-sensitive protein and type II collagen expression during fracture healing are potential targets for Sox9 regulation
34. Genetic expression of extracellular matrix proteins correlates with histologic changes during fracture repair
35. Exogenous fibroblast growth factors-1 and -2 do not accelerate fracture healing in the rabbit
36. Tibial segmental defect repair: Chondrogenesis and biomechanical strength modulated by basic fibroblast growth factor
37. Acidic fibroblast growth factor (aFGF) injection stimulates cartilage enlargement and inhibits cartilage gene expression in rat fracture healing
38. Combination of growth factors inhibits bone ingrowth in the bone harvest chamber