Randomised, double blind, multicentre, placebo controlled study of sulodexide in the treatment of venous leg ulcers

Thrombosis and Haemostasis

Volumn 87, Issue 6, 2002, Pages 947-952

  Coccheri, Sergio ^a   Scondotto, Gaetano ^a   Agnelli, Giancarlo ^a   Aloisi, Daniele ^a   Palazzini, Ernesto ^a   Zamboni, Villiam ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Chronic venous insufficiency; Glycosaminoglycans; Sulodexide; Venous leg ulcer

Indexed keywords

FIBRINOGEN; GLYCOSAMINOGLYCAN; PLACEBO; SULODEXIDE; VESSEL DUE F; FIBRINOLYTIC AGENT;

ABDOMINAL PAIN; ADULT; AGED; ARTICLE; BANDAGE; CHRONIC VEIN INSUFFICIENCY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG ERUPTION; DRUG TOLERABILITY; EPIGASTRIC PAIN; FEMALE; HEADACHE; HUMAN; LEG COMPRESSION; LEG ULCER; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ULCER HEALING; WOUND CARE; DRUG EFFECT; LEG; METABOLISM; MIDDLE AGED; PATHOLOGY; TIME; TREATMENT OUTCOME; VARICOSIS; WOUND HEALING;

AGED; BANDAGES; DOUBLE-BLIND METHOD; FEMALE; FIBRINOGEN; FIBRINOLYTIC AGENTS; GLYCOSAMINOGLYCANS; HUMANS; LEG; MALE; MIDDLE AGED; PLACEBOS; TIME FACTORS; TREATMENT OUTCOME; VARICOSE ULCER; WOUND HEALING;

EID: 0036285389     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1613116     Document Type: Article

References (20)

1. Investigation of chronic venous insufficiency: A consensus statement
2. Chronic venous disorders of the leg: Epidemiology, outcomes, diagnosis and management. Consensus Statement
3. Socioeconomic impact of chronic venous insufficiency and leg ulcers
4. Pathophysiology of venous leg ulceration - An update
5. A systemic review of compression treatment for venous leg ulcers
6. Adjuvant systemic drug therapy in venous ulcers
7. Pharmacological actions of sulodexide
8. Review of pharmacodynamics, pharmacokinetics, and therapeutic properties of sulodexide
9. Glycosaminoglycans administration decreases high fibrinogen plasma levels in diabetic patients
10. 131I-labelled fast-moving heparin after single intravenous and oral administration on man at different doses
11. Double-blind, double-dummy, randomized, multicentre clinical assessment of the efficacy, tolerability and dose-effect relationship of sulodexide in chronic venous insufficiency
12. Treatment of venous ulcers with sulodexide
13. Guidelines for testing drugs for chronic venous insufficiency
14. Efficacy of Daflon 500 mg in venous leg ulcer healing: A double-blind, randomized, controlled versus placebo trial in 107 patients
15. The beneficial augmentative effect of micronised purified flavonoid fraction (MPFF) on the healing of leg ulcers: An open, multicentre, controlled, randomised study
16. Oral pentoxifylline for treatment of venous leg ulcers
17. Randomised, double blind placebo controlled trial of pentoxifylline in the treatment of venous ulcers
18. Randomised trial of oral aspirin for chronic venous leg ulcers
19. Treatment of venous lipodermatosclerosis and ulceration in venous hypertension by elastic compression and fibrinolytic enhancement with defibrotide
20. Effects of glycosaminoglycans on platelet and leucocyte function: Role of N-sulfation