Slow release iodine preparation and wound healing: In vitro effects consistent with lack of in vivo toxicity in human chronic wounds

British Journal of Dermatology

Volumn 146, Issue 3, 2002, Pages 365-374

  Zhou, L H ^a   Nahm, W K ^a   Badiavas, E ^a   Yufit, T ^a   Falanga, V ^a,b  

^a ROGER WILLIAMS MEDICAL CENTER   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antiseptic; Cadexomer iodine; Collagen; Fibroblast; Thymidine uptake; Wounds

Indexed keywords

ANTIINFECTIVE AGENT; CADEXOMER IODINE; MESSENGER RNA; PROCOLLAGEN; THYMIDINE DERIVATIVE;

ADULT; AGED; ARTICLE; CELL DEATH; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CLINICAL ARTICLE; COLLAGEN SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; EPITHELIZATION; EXPLANT; FEMALE; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; MALE; NEWBORN; PREPUCE; PRIORITY JOURNAL; RNA SYNTHESIS; SKIN; SKIN BIOPSY; SKIN TOXICITY; SLOW RELEASE FORMULATION; STAINING; WOUND; WOUND HEALING;

ADULT; AGED; AGED, 80 AND OVER; ANTI-INFECTIVE AGENTS, LOCAL; CELL DIVISION; CELL SURVIVAL; CELLS, CULTURED; CHRONIC DISEASE; DELAYED-ACTION PREPARATIONS; DRUG ADMINISTRATION SCHEDULE; FEMALE; FIBROBLASTS; HUMANS; INFANT, NEWBORN; IODINE COMPOUNDS; MALE; MICROSPHERES; MIDDLE AGED; PROCOLLAGEN; RNA, MESSENGER; SKIN; SKIN ULCER; THYMIDINE; WOUND HEALING;

EID: 0036284451     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.2002.04605.x     Document Type: Article

References (38)

1. Experimental study of the local application of silver sulfadiazine, cefsulodin and povidone-iodine in burns
2. A controlled model of moist wound healing: Comparison between semi-permeable film, antiseptics and sugar paste
3. Comparison of the effects of commonly used wound agents on epithelialization and neovascularization
4. Topical antimicrobial toxicity
5. A modified technique of delayed primary closure using a povidone iodine wick: Influence on wound healing in an experimental model
6. Iodosorb and iodoflex
7. Controlled trial of Iodosorb in chronic venous ulcers
8. A randomized trial comparing cadexomer iodine and standard treatment in the out-patient management of chronic venous ulcers
9. Cadexomer iodine in ulcers colonised by Pseudomonas aeruginosa
10. Multicenter trial of cadexomer iodine to treat venous stasis ulcer
11. Dermal fibroblasts from venous ulcers are unresponsive to the action of transforming growth factor-beta 1
12. A study of the effect of cadexomer iodine in the treatment of venous leg ulcers
13. Cavity foot ulcers in diabetic patients: A comparative study of cadexomer iodine ointment and standard treatment. An economic analysis alongside a clinical trial
14. A randomized trial of cadexomer iodine in decubitus ulcers
15. The evaluation of a cadexomer iodine wound dressing on methicillin resistant Staphylococcus aureus (MRSA) in acute wounds
16. In-patient treatment of chronic varicose venous ulcers. A randomized trial of cadexomer iodine versus standard dressings
17. Treatment of venous leg ulcers with cadexomer iodine with particular reference to iodine sensitivity
18. 3 syndrome
19. A retrospective review of the use of cadexomer iodine in the treatment of chronic wounds
20. Iodine released from the wound dressing Iodosorb modulates the secretion of cytokines by human macrophages responding to bacterial lipopolysaccharide
21. Cadexomer-iodine ointment shows stimulation of epidermal regeneration in experimental full-thickness wounds
22. Cadexomer iodine formulations may modulate the redox environment of wounds
23. Transforming growth factor-beta: Selective increase in glycosaminoglycan synthesis by cultures of fibroblasts from patients with progressive systemic sclerosis
24. Fixation in immunocytochemistry
25. Hypoxia upregulates the synthesis of TGF-beta 1 by human dermal fibroblasts
26. 3H]thymidine uptake and alpha 1(I) procollagen mRNA expression in systemic sclerosis skin fibroblasts - An in situ hybridization study
27. Protein measurement using bicinchoninic acid: Elimination of interfering substances
28. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
29. Enhanced collagen synthesis and transcription by peak E, a contaminant of L-tryptophan preparations associated with the eosinophilia myalgia syndrome epidemic
30. Cloning and characterization of five overlapping cDNAs specific for the human pro alpha 1(I) collagen chain
31. Classifications for wound bed preparation and stimulation of chronic wounds
32. Can antimicrobials be effective without impairing wound healing - Evaluation of cadexomer-iodine ointment
33. An appraisal of povidone-iodine and wound healing
34. A study to assess the effects of a new Betadine cream formulation compared with a standard topical treatment regimen for burns
35. Controversies in topical wound management: Wound cleansing and wound disinfection
36. Effects of Iodosorb on healing of full thickness wounds on pigs
37. Disinfectants, antiseptics and antibiotics
38. Oxygen metabolites from phagocytes