Utility of nuclear magnetic resonance spectroscopy to characterize the structure of dexamethasone sodium phosphate inclusion complexes with cyclodextrins in solution and to analyze potential competitive effects

Journal of Pharmaceutical Sciences

Volumn 91, Issue 6, 2002, Pages 1536-1547

  Echezarreta Lopez M M ^a   Perdomo Lopez I ^a   Estrada, E ^a   Vila Jato, J L ^a   Torres Labandeira, J J ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Cyclodextrins; Glucocorticoids; Micelles; Molecular modeling; Nuclear magnetic resonance spectroscopy; Ophthalmic solutions

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; 2,6 O DIMETHYL BETA CYCLODEXTRIN; BENZALKONIUM CHLORIDE; CYCLODEXTRIN DERIVATIVE; DEXAMETHASONE SODIUM PHOSPHATE; EYE DROPS; GAMMA CYCLODEXTRIN; GLUCOCORTICOID; POLYMYXIN B; TRIMETHOPRIM;

ARTICLE; COMPLEX FORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ANALYSIS;

EID: 0036282897     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10145     Document Type: Article

References (30)

1. Studies on dexamethasone, a new synthetic steroid in rheumatoid arthritis - A preliminary report. Adrenal corticol metabolic and early clinical effects
2. Dexamethasone
3. A comparison of the bioavailability and potency of dexamethasone phosphate and sulphate in man
4. Pharmacokinetics of dexamethasone and its phosphate ester
5. Inclusion complexations of steroid hormones with cyclodextrins in water and in solid phase
6. Formation of cyclodextrin inclusion complexes with corticosteroids: Theirs characterization and stability
7. Effects of cyclodextrin derivatives on bioavailability of ketoprofen
8. Improvement of the in vitro dissolution of praziquantel by complexation with α-, β- and γ-cyclodextrins
9. Characterization of itraconazole/2-hydroxypropyl-β-cyclodextrin inclusion complex in aqueous propylene glycol solution
10. Cyclodextrins: Their future in drug formulation and delivery
11. Solubilization and stabilization of drugs through cyclodextrin complexation
12. Stabilizing effect of inorganic phosphate salts on antibiotic-steroid ophthalmic preparations
13. Enhancement of bioavailability of cinnarizine from its β-cyclodextrin complex on oral administration with DL-phenylalanine as a competing agent
14. Competitive reactions of cyclodextrin inclusion compounds
15. Interactions between preservatives and 2-hydroxypropyl-β-cyclodextrin
16. 1H-NMR studies
17. A spectrophotometric investigation of the interaction of iodine with aromatic hydrocarbons
18. Simple prediction of stability constants for inclusion complexes of β-cyclodextrin with various drug molecules using β-cyclodextrin bonded phases (Cyclobond I column)
19. Phase-solubility techniques
20. Reserches sur la formation de complexes mineraux en solution et sur leur stabilité
21. Topography of cyclodextrin inclusion complexes. Part 37. Crystal structure of anhydrous heptakis-(2,6-di-O-methyl) cyclomaltoheptaose (dimethyl-beta-cyclodextrin)
22. The structure of the cyclodextrin complex. XX. Crystal structure of uncomplexed hydrated gamma-cyclodextrin
23. 9α-Fluoro-16α-methyl-11β, 17α,21-trihydroxy-1,4-pregnadiene-3,20-dione[dexamethasone]
24. Ligand-cyclodextrin complexes
25. Considerations in the use of hydroxypropyl-β-cyclodextrin in the formulation of aqueous ophthalmic solutions of hydrocortisone
26. High-field nuclear magnetic resonance techniques for the investigation of a β-cyclodextrin:indomethacin inclusion complex
27. Enantioseparation of amino-glutethimide with cyclodextrins in capillary electrophoresis and studies of selector-select and interactions using NMR spectroscopy and electrosprary ionization mass spectrometry
28. Applications of computacional chemistry to the study of cyclodextrins
29. Interaction of naproxen with α-, β- and γ-hydroxypropyl cyclodextrins in solution and in solid state
30. Molecular modeling (MM2 and PM3) and experimental (NMR and thermal analysis) studies on the inclusion complex of salbutamol and β-cyclodextrin