Sodium pump isoform expression in heart failure: Implication for treatment

Basic Research in Cardiology, Supplement

Volumn 97, Issue 1, 2002, Pages 25-30

  Müller Ehmsen, Jochen ^a   McDonough, Alicia A ^a   Farley, Robert A ^a   Schwinger, Robert H G ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Cardiac glycosides; Heart failure; Isoforms; Na, K ATPase; Sodium pump

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) APHA1 BETA1; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) APHA2 BETA1; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) APHA3 BETA1; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) INHIBITOR; CALSEQUESTRIN; GLYCOSIDE; ISOENZYME; OUABAIN; POTASSIUM; UNCLASSIFIED DRUG;

BIOCHEMISTRY; CELLULAR DISTRIBUTION; DISEASE ACTIVITY; DRUG EFFECT; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SPECIFICITY; GENE THERAPY; HEART; HEART ATRIUM FIBRILLATION; HEART FAILURE; HEART LEFT VENTRICLE; HEART MUSCLE CONTRACTILITY; HETEROZYGOSITY; HUMAN; KIDNEY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; OOCYTE; PROTEIN EXPRESSION; PROTEIN TARGETING; REVIEW; SKELETAL MUSCLE; TISSUE SPECIFICITY; TURNOVER TIME; XENOPUS; YEAST CELL;

ANIMALS; CARDIAC OUTPUT, LOW; HEART; HUMANS; ISOENZYMES; NA(+)-K(+)-EXCHANGING ATPASE; SUBCELLULAR FRACTIONS; TISSUE DISTRIBUTION;

EID: 0036282414     PISSN: 01759418     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (22)

1. Ouabain augments Ca(2+) transients in arterial smooth muscle without raising cytosolic Na(+)
2. Tissue-specific expression of the Na, K-ATPase beta3 subunit. The presence of beta3 in lung and liver addresses the problem of the missing subunit
3. Isozymes of the Na-K-ATPase: Heterogeneity in structure, diversity in function
4. Transport and pharmacological properties of nine different human Na, K-ATPase isozymes
5. Cardiac glycoside receptor, (Na+ + K+)-ATPase activity and force of contraction in rat heart
6. Multiplicity of cardiac glycoside receptors in human heart
7. Hemodynamic effects of intravenous digoxin in patients with severe heart failure initially treated with diuretics and vasodilators
8. Relation of sodium pump inhibition to positive inotropy at low concentrations of ouabain in rat heart muscle
9. Identification of a specific role for the Na, K-ATPase alpha 2 isoform as a regulator of calcium in the heart
10. Na+ pump low and high ouabain affinity alpha subunit isoforms are differently distributed in cells
11. +-concentration in isolated human myocardium
12. The sodium pump needs its beta subunit
13. Subcellular distribution of sodium pump isoform subunits in mammalian cardiac myocytes
14. Ouabain and substrate affinities of human Na, K-ATPase α1β1, α2β1 and α3β1 when expressed separately in yeast cells
15. Region specific regulation of sodium pump isoform and Na, Ca-exchanger expression in the failing human heart - Right atrium vs. left ventricle
16. Relation of left ventricular function and Na, K-pump concentration in suspected idiopathic dilated cardiomyopathy
17. Enhanced sensitivity of the failing human myocardium to cardiac glycosides and Na(+)-channel activators
18. Reduced sodium pump alpha1, alpha3, and beta1-isoform protein levels and Na+, K+-ATPase activity but unchanged Na+-Ca2+ exchanger protein levels in human heart failure
19. Characterisation of Na/K-ATPase, its isoforms, and the inotropic response to ouabain in isolated failing human hearts
20. A putative fourth Na+, K(+)-ATPase alpha-subunit gene is expressed in testis
21. Identification of three isozyme proteins of the catalytic subunit of the Na, K-ATPase in rat brain
22. Regional expression of sodium pump subunits isoforms and Na+-Ca++ exchanger in the human heart