Delivery of antisense oligonucleotides to PC12 cells

Neuroscience Research

Volumn 43, Issue 1, 2002, Pages 81-86

  Acosta, Rosalinda ^a   Montañez, Cecilia ^a   Gómez, Pablo ^a   Cisneros, Bulmaro ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Antisense oligonucleotides; Antisense stability; Liposomes; PC12 cells; Phosphorothioate oligonucleotides

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; ESTER DERIVATIVE; LIPOSOME; PHOSPHOROTHIOIC ACID;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL LINE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG UPTAKE; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CULTURE MEDIA; CULTURE MEDIA, SERUM-FREE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG STABILITY; FLUORESCENT DYES; LIPOSOMES; MACROMOLECULAR SUBSTANCES; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PC12 CELLS; PHOSPHORIC DIESTER HYDROLASES; RATS; TRANSFECTION;

EID: 0036281091     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-0102(02)00014-7     Document Type: Article

References (15)

1. In vitro pharmacokinetics of phosphorothioate antisense oligonucleotide
2. Reduced levels of calmodulin in PC12 cells induced by stable expression of calmodulin antisense RNA inhibits cell proliferation and induces neurite outgrowth
3. Expression of HuD protein is essential for initial phase of neuronal differentiation in rat pheochromocytoma PC12 cells
4. Intracellular disposition and metabolism of fluorescently-labeled unmodified and modified oligonucleotides microinjected into mammalian cells
5. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
6. The cellular delivery of antisense oligonucleotides and ribozyme
7. Aspects of the transport and delivery of antisense oligonucleotides
8. Cationic liposomes improve stability and intracellular delivery of antisense oligonucleotides into CaSki cells
9. Antisense oligonucleotides: Promise and reality
10. Antisense studies in PC12 cells suggest a role for H218, a sphingosine 1-phosphate receptor, in growth-factor-induced cell-cell interaction and neurite outgrowth
11. Overexpression of Ca2+/calmodulin-dependent protein kinase II in PC12 cells alters cell growth, morphology, and nerve growth factor-induced differentiation
12. The RNA-binding protein HuD is required for GAP-43 mRNA stability, GAP-43 gene expression and PKC-dependent neurite outgrowth in PC12 cells
13. Fluorescence microscopic comparison of the binding of phosphodiester and phosphorothioate (antisense) oligodeoxyribonucleotides to subcellular structures, including intermediate filaments, the endoplasmic reticulum, and the nuclear interior
14. Delivery of antisense oligonucleotides to neuroblastoma cells
15. Antisense strategies in neurobiology