Mechanism of the antitussive effect of azelastine in guinea pigs

Arzneimittel-Forschung/Drug Research

Volumn 52, Issue 6, 2002, Pages 441-447

  Ito, Nobuaki ^a   Shioya, Takanobu ^a   Watanabe, Akiko ^a   Sano, Masaaki ^a   Sasaki, Masahiro ^a   Miura, Mamoru ^a  

^a AKITA UNIVERSITY   (Japan)

Author keywords

Azelastine hydrochloride, antitussive effect, guinea pigs; Azeptin ; Capsaicin; CAS 790307 93 0; Substance P

Indexed keywords

ANTITUSSIVE AGENT; AZELASTINE; CAPSAICIN; SUBSTANCE P;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; COUGHING; DOSE RESPONSE; DRUG MECHANISM; FEMALE; GUINEA PIG; INHIBITION KINETICS; LUNG LAVAGE; NONHUMAN; RADIOIMMUNOASSAY; SENSORY NERVE; STATISTICAL SIGNIFICANCE;

EID: 0036280587     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1299912     Document Type: Article

References (27)

1. Managing cough as a defense mechanism and as a symptom; A concensus panel report of the American College of Chest Physicians
2. Exertional dyspnea and cough preludes to acute attacks of bronchial asthma
3. Chronic cough as the sole presenting manifestation of bronchial asthma
4. Pharmacological and toxicological properties of azelastine, a novel antiallergic agent
5. Inhibition by azelastine of the immunologically induced histamine release from isolated guinea pig mast cells
6. Anti-allergic effect of azelastine hydrochloride on immediate type hypersensitivity reactions in vitro and in vivo
7. Effect of azelastine on the down regulation of β-adrenoceptors in guinea pig lung
8. Cough threshold for capsaicin increases by azelastine in patients with cough-variant asthma
9. Antitussive effect of azelastine hydrochloride in patients with bronchial asthma
10. Effect of azelastine on sulphur dioxide induced impairment of ciliary motility in airway epithelium
11. A case of prolonged cough associated with mycoplasma pneumonia showing good response to azelastine
12. Selective effect of general anesthetics on reflex bronchoconstrictor responses in dogs
13. Neural endopeptidase inhibitors potentiate substance P- and capsaicin- induced cough in awake guinea pigs
14. Angiotensin-converting enzyme inhibitor and danazol increases sensitivity of cough reflex in female guinea pigs
15. Recombinant human enkephalinase (neutral endopeptidase) prevents cough induced by tachykinins in awake guinea pigs
16. Post-synaptic potentiation of vagal contractile responses by neurokinin A
17. Isometric technique measuring tracheal smooth muscle force in vivo in guinea pig
18. Elevated substance P content in induced sputum from patients with asthma and patients with chronic bronchitis
19. Substance P-immunoreactivity sensory nerves in the lower respiratory tract of varios mammals including man
20. Role of substance P in cough during bronchoconstriction in awake guinea pigs
21. Release of multiple tachykinins from capsaicin-sensitive sensory nerves in the lung by bradykinin, histamine, dimethylphenyl piperadinium, and vagal nerve stimulation
22. Capsaicin-induced bronchoconstriction and neuropeptide release in guinea pig perfused lungs
23. Evidence for substance P as an endogenous substance causing cough in guinea pigs
24. Inhibitory effect of anti-allergic drugs on cholinergic neurotransmissions of guinea pig bronchial muscle in vitro
25. Effect of azelastine on substance P content in bronchoalveolar and nasal lavage fluids of patients with allergic asthma
26. The effect of oral terfenadine on the sensitivity of the cough reflex in normal volunteers
27. Terfenadine, a potent histamine Hi-receptor antagonist in the treatment of grass pollen sensitive asthma