Partition of N-monodemethylated phenothiazine drugs to phosphatidylcholine bilayer vesicles studied by second-derivative spectrophotometry

Journal of Pharmaceutical Sciences

Volumn 91, Issue 6, 2002, Pages 1568-1572

  Borchard, Gerrit ^a   Cassará, María Luz ^a   Roemelé, Peter E H ^a   Florea, Bogdan I ^a   Junginger, Hans E ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

N monodemethylated metabolites; Phenothiazines; Second derivative spectra

Indexed keywords

CHLORPROMAZINE; PHENOTHIAZINE DERIVATIVE; PROMAZINE; TRIFLUPROMAZINE;

ABSORPTION SPECTROSCOPY; ARTICLE; CALCULATION; DRUG DETERMINATION; PARTITION COEFFICIENT; SPECTRAL SENSITIVITY; SPECTROPHOTOMETRY;

EID: 0036279246     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10121     Document Type: Article

References (18)

1. Metabolism of phenothiazine and butyrophenone antipsychotic drugs
2. Model metabolites of chlorpromazine and promazine: Relative activities in some pharmacological and behavioral tests
3. A comparative study of chlorpromazine and its demethylated derivatives: Potency and tissue distribution
4. Concentrations of chlorpromazine and two of its active metabolites in plasma and cerebrospinal fluid of psychotic patients treated with fixed drug doses
5. Ionization constants, octanol partition coefficients and cholinesterase inhibitor constants for chlorpromazine and its metabolites
6. Determination of dissociation constants of sparingly soluble phenothiazine derivatives by second-derivative spectrophotometry
7. Simultaneous determination of aspirin and caffeine in the presence of pharmaceutical additives by curve fitting the second-derivative spectra
8. Second derivative spectrophotometric determination of partition coefficients of chlorpromazine and promazine between lecithin bilayer vesicles and water
9. Effects of particle size and cholesterol content on the partition coefficients of chlorpromazine and triflupromazine between phosphatidylcholine-cholesterol bilayers of unilamellar vesicles and water studied by second-derivative spectrophotometry
10. Partition of chlorpromazine into lipid bilayer membranes: The effect of membrane structure and composition
11. Biphasic nature of the binding of cationic amphipaths with artificial and biological membranes
12. Differential binding of chlorpromazine to human blood cells: Application of the hygroscopic desorption method
13. Partition of amphiphilic molecules into phospholipid vesicles and human erythrocyteghosts
14. 3] drugs (Chlorpromazine, Triflupromazine and Promazine)
15. The determination of phosphorus in organic compounds on the centimilligram scale
16. Effect of the degree of polynomials in the Savitzky-Golay method for calculation of second-derivative spectra
17. Smoothing and differentiation of data by simplified least squares procedures