Synthesis of 2-[18F]fluoro-L-tyrosine via regiospecific fluoro-de-stannylation

Applied Radiation and Isotopes

Volumn 57, Issue 2, 2002, Pages 185-191

  Hess, E ^a   Sichler, S ^b   Kluge, A ^b   Coenen, H H ^a  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b ABX Advanced Biochemical Compounds GmbH   (Germany)

Author keywords

2 18F Fluoro L tyrosine; 6 18F Fluoro L dopa; Electrophilic 18F fluorination; Fluoro de stannylation; PET tracer

Indexed keywords

AMINO ACIDS; FLUORINE; HYDROLYSIS; ISOMERS; ISOTOPES; POSITRON EMISSION TOMOGRAPHY; PROTEINS;

ELECTROPHILIC PREPARATION;

RADIATION;

2 FLUOROTYROSINE F 18; HYDROBROMIC ACID; IMIDAZOLE DERIVATIVE; TRACER; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; ENANTIOMER; FLUORINATION; FLUORO DESTANNYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN METABOLISM;

EID: 0036276429     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8043(02)00091-X     Document Type: Article

References (14)

1. Biochemistry and evaluation of fluoroamino acids
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3. Direct electrophilic radiofluorination of phenylalanine, tyrosine and dopa
4. 18F]fluoro-L-tyrosine, a new PET-tracer for protein synthesis
5. 18F]F-L-Dopa
6. 18F reaction
7. 18F]fluoro-L-tyrosine
8. 18F]fluoride
9. 18F]F-L-dopa
10. 2
11. 2 production
12. 2 targetry for 19MeV protons
13. Die Selbstregeneration von Stereozentren (SRS) - Anwendungen, Grenzen und Preisgabe eines Syntheseprinzips