Investigating the TNP-OVA and direct popliteal lymph node assays for the detection of immunostimulation by drugs associated with anaphylaxis in humans

Journal of Applied Toxicology

Volumn 22, Issue 3, 2002, Pages 177-183

  Gutting, Bradford W ^a   Updyke, Lawrence W ^a   Amacher, David E ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Diclofenac; Drug hypersensitivity; Drug induced anaphylaxis; Glafenine; IgE; Popliteal lymph node assay (PLNA); Reporter antigen; TNP OVA; Zomepirac

Indexed keywords

DICLOFENAC; GLAFENINE; HAPTEN; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; OVALBUMIN; TRINITROPHENYL; ZOMEPIRAC;

ANAPHYLAXIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCING CELL; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ARTICLE; BIOASSAY; CONTROLLED STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG HYPERSENSITIVITY; IMMUNOMODULATION; IMMUNOSTIMULATION; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; ANAPHYLAXIS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DICLOFENAC; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FEMALE; GLAFENINE; HAPTENS; HUMANS; IMMUNOGLOBULIN E; LOCAL LYMPH NODE ASSAY; LYMPH NODES; MICE; MICE, INBRED BALB C; ORGAN SIZE; OVALBUMIN; SPECIFIC PATHOGEN-FREE ORGANISMS; TOLMETIN; TOXICITY TESTS;

ANIMALIA; MURINAE;

EID: 0036274776     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jat.847     Document Type: Article

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