The effect of controlled release tablet performance and hydrogel strength on in vitro/in vivo correlation

Pharmaceutical Development and Technology

Volumn 7, Issue 2, 2002, Pages 155-168

  Roshdy, Maichel N ^a   Schnaare, Roger L ^a   Sugita, Edwin T ^a   Schwartz, Joseph B ^a  

^a UNIVERSITY OF THE SCIENCES   (United States)

Author keywords

Beagle dogs; Carbomer; Controlled release; Gel strength; Hydrogel tablet; Hydroxypropyl cellulose; Hydroxypropyl methylcellulose; In vitro in vivo correlation; Rheology; Theophylline

Indexed keywords

CARBOMER; HYDROXYPROPYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; LACTOSE; POLYMER; THEOPHYLLINE DERIVATIVE;

ARTICLE; BOLUS INJECTION; CONTROLLED RELEASE FORMULATION; DOG; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CONCENTRATION; DRUG FORMULATION; DRUG SOLUBILITY; FLOW KINETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEL; PRIORITY JOURNAL; SLOW DRUG RELEASE; TABLET; TABLET HARDNESS;

ANIMALS; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DOGS; HYDROGEL; LACTOSE; MALE; METHYLCELLULOSE; OXAZINES; POLYVINYLS; SOLUBILITY; TABLETS; THEOPHYLLINE;

EID: 0036267128     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-120003484     Document Type: Article

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