Pardaxin stimulation of phospholipases A2 and their involvement in exocytosis in PC-12 cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 301, Issue 3, 2002, Pages 953-962

  Bloch Shilderman, Eugenia ^a   Abu Raya, Saleh ^a   Trembovler, Victoria ^a   Boschwitz, Hassia ^b   Gruzman, Arie ^a   Linial, Michal ^b   Lazarovici, Philip ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ARACHIDONIC ACID; ARACHIDONYL TRIFLUOROMETHYL KETONE; BOTULINUM TOXIN; BROMOENOL LACTONE; CALCIUM; DOPAMINE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N ETHYLMALEIMIDE; PARDAXIN; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PROSTAGLANDIN E2;

ANIMAL CELL; ARTICLE; CELL STRAIN; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXOCYTOSIS; NEUROTRANSMITTER RELEASE; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; EXOCYTOSIS; FISH VENOMS; NEUROTOXINS; PC12 CELLS; PHOSPHOLIPASES A; RATS;

EID: 0036264462     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.301.3.953     Document Type: Article

References (43)

1. Characterization of Pardaxin-induced dopamine release from PC-12 cells: The role of calcium and eicosanoids
2. Pardaxin, a new pharmacological tool to stimulate the arachidonic acid cascade in PC-12 cells
3. 2
4. Isolation, characterization and synthesis of a novel pardaxin isoform
5. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and in vivo
6. Calcium-dependent and -independent acetylcholine release from electric organ synaptosomes by pardaxin: Evidence of a biphasic action of an excitatory neurotoxin
7. Calcium-induced ERK activation in human T lymphocytes
8. Calcium action in synaptic transmitter release
9. Involvement of phosphatidate phosphohydrolase in arachidonic acid mobilization in human amnionic WISH cells
10. 2
11. 1 macrophages
12. 2
13. Synaptotagmin I- and II-deficient PC-12 cells exhibit calcium-independent, depolarization-induced neurotransmitter release from synaptic-like microvesicles
14. Involvement of extracellular signal-regulated kinase (ERK) in pardaxin-induced dopamine release from PC-12 cells
15. 2+ and secretory-vesicle dynamics
16. 2+ and drives membrane fusion
17. cis-unsaturated fatty acids induce the fusion of chromaffin granules aggregated by synexin
18. 2
19. Identification of a novel inhibitor of mitogen-activated protein kinase
20. The relationship between arachidonic acid release and catecholamine secretion from cultured bovine adrenal chromaffin cells
21. 2+-induced and GTP analogue-induced catecholamine release from permeabilized adrenal chromaffin cells
22. Fusion of neurotransmitter vesicles with target membrane is calcium independent in a cell-free system
23. 2 in dopamine secretion by rat neuronal PC-12 cells
24. Purification and pore-forming activity of two hydrophobic polypeptides from the secretion of the Red Sea Moses sole (Pardachirus marmoratus)
25. Pardaxin induces exocytosis in bovine adrenal medullary chromaffin cells independent of calcium
26. 2 is phosphorylated and activated by MAP kinase
27. Assembly of SNARE core complexes prior to neurotransmitter release sets the readily releasable pool of synaptic vesicles
28. 2+-independent dopamine release from striatal slices: A possible role of reverse dopamine transport
29. 2 from rat neuronal cells and its possible function in the regulation of catecholamine secretion
30. Structure and function of tetanus and botulinum neurotoxins
31. Is NSF a fusion protein
32. 2-treated presynaptic membranes in vitro
33. Assembly and disassembly of a ternary complex of synaptobrevin, syntaxin, and SNAP-25 in the membrane of synaptic vesicles
34. Eicosanoids in synaptic transmission
35. Rapid extraction of arachidonic acid metabolites from biological samples using octadecylsilyl silica
36. 2 in fatty acid incorporation, phospholipid remodeling, lysophosphatidylcholine generation, and secretagogue-induced arachidonic acid release in pancreatic islets and insulinoma cells
37. Botulinum toxin inhibits arachidonic acid release associated with acetylcholine release from PC-12 cells
38. 2 and arachidonic acid-mediated mechanism of neuroexocytosis: A possible target of botulinum neurotoxin A other than SNAP-25
39. Acetylcholine exocytosis in PC-12 cells deficient in SNAP-25
40. SNAP receptors implicated in vesicle targeting and fusion
41. The synaptic vesicle cycle: A cascade of protein-protein interactions
42. Membrane fusion machinery: Insights from synaptic proteins
43. 2 by cyanide in PC-12 cells