Hemochromatosis and porphyria

Seminars in Gastrointestinal Disease

Volumn 13, Issue 2, 2002, Pages 109-119

  Lambrecht, Richard W ^a   Bonkovsky, Herbert L ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINOLEVULINATE SYNTHASE; ALPHA2B INTERFERON; AMINOLEVULINIC ACID; IRON; PORPHYRINOGEN; REACTIVE OXYGEN METABOLITE; RIBAVIRIN; UROPORPHYRIN; UROPORPHYRINOGEN DECARBOXYLASE;

ADULT; ARTICLE; CASE REPORT; DIAGNOSTIC APPROACH ROUTE; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME INHIBITION; FATIGUE; GENE; GENE HFE; HEMOCHROMATOSIS; HUMAN; IRON METABOLISM; IRON OVERLOAD; LABORATORY DIAGNOSIS; MALAISE; MALE; OXIDATION; PATHOGENESIS; PHLEBOTOMY; PORPHYRIA; PORPHYRIA CUTANEA TARDA; PRIMARY MEDICAL CARE; PRURITUS; SKIN MANIFESTATION;

EID: 0036260615     PISSN: 10495118     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Iron and chronic viral hepatitis
2. Porphyrin and heme metabolism and the porphyrias
3. The porphyrias
4. Increased frequency of haemochromatosis C:ys 282Tyr mutation in sporadic porphyria cutanea tarda
5. The C282Y mutation in the haemochromatosis gene (HFE) and hepatitis C virus infection are independent cofactors for porphyria cutanea tarda in Australian patients
6. Porphyria cutanea tarda, hepatitis C and HFE gene mutations in North America
7. High prevalence of the His 63Asp HFE mutation in Italian patients with porphyria cutanea tarda
8. Hemochromatosis genes and other factors contributing to the pathogenesis of porphyria cutanea tarda
9. Porphyria cutanea tarda in Brazilian patients: Association with hemochromatosis C282Y mutation and hepatitis C virus infection
10. Uroporphyrinogen decarboxylase structural mutant (Gly 281 > Glu) in a case of porphyria
11. A point mutation in the coding region of uroporphyrinogen decarboxylase associated with familial porphyria cutanea tarda
12. Characterization of a new mutation (R292G) and a deletion at the human uroporphyrinogen decarboxylase locus in two patients with hepatoerythropoietic porphyria
13. Identification of a new mutation responsible for hepatoerythropoietic porphyria
14. Immunoreactive uroporphyrinogen decarboxylase in the liver in porphyria cutanea tarda
15. Porphyria cutanea tarda: A multifactorial disease
16. Uroporphyrin accumulation in cultured chick embryo hepatocytes: Comparison of 2,3,7,8-tetrachloro-p-dioxin and 3,4,3′,4′-tetrachlorobiphenyl
17. Inhibition of uroporphyrinogen decarboxylase activity. The role of cytochrome P-450-mediated uroporphyrinogen oxidation
18. Synergy of iron in the toxicity and carcinogenicity of polychlorinated biphenyls (PCBs) and related chemicals
19. Hepatocarcinogenicity of hexachlorobenzene in rats and the sex difference in hepatic iron status and development of porphyria
20. In vitro inhibitory effect on porphyrinogen carboxylase of liver extracts from TCDD treated mice
21. Chemically induced formation of an inhibitor of hepatic uroporphyrinogen decarboxylase in inbred mice with iron overload
22. Role of cytochrome P450 in porphyria caused by halogenated aromatic compounds
23. Uroporphyrin accumulation produced by halogenated biphenyls in chick-embryo hepatocytes. Reversal of the accumulation by piperonyl butoxide
24. Ascorbic acid inhibits chemically-induced uroporphyria in ascorbate-requiring rats
25. Ascorbic acid deficiency in porphyria cutanea tarda
26. Role of iron in the hydrogen peroxidedependent oxidation of hexahydroporphyrins (porphyrinogens): A possible mechanism for the exacerbation by iron of hepatic uroporphyria
27. Oxidation of uroporphyrinogen by methylcholanthrene-induced cytochrome P450. Essential role of cytochrome P-450d
28. Purification and properties of uroporphyrinogen decarboxylase from human erythrocytes. A single enzyme catalyzing the four sequential decarboxylations of uroporphyrinogens I and III
29. Genetic variation of iron-induced uroporphyria in mice
30. Iron and the liver: Acute effects of iron-loading on hepatic heme synthesis of rats. Role of decreased activity of 5-aminolevulinate dehydrase
31. Mechanism of synergistic induction of hepatic heme oxygenase by glutethimide and iron: Studies in cultured chick embryo liver cells