Pathogenesis of multiple sclerosis: An update on immunology

Current Opinion in Neurology

Volumn 15, Issue 3, 2002, Pages 227-231

  Hemmer, Bernhard ^a   Cepok, Sabine ^a   Nessler, Stefan ^a   Sommer, Norbert ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CYTOKINE PRODUCTION; DEMYELINATION; IMMUNOLOGY; MULTIPLE SCLEROSIS; NONHUMAN; PATHOGENESIS; REVIEW; T LYMPHOCYTE; TH1 CELL;

ANIMALS; B-LYMPHOCYTES; CENTRAL NERVOUS SYSTEM; CYTOKINES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; HUMANS; IMMUNE SYSTEM; KILLER CELLS, NATURAL; MULTIPLE SCLEROSIS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0036260390     PISSN: 13507540     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019052-200206000-00001     Document Type: Review

References (48)

1. The T lymphocyte in experimental allergic encephalomyelitis
2. Migratory activity and functional changes of green flucrescent effector cells before and during experimental autoimmune encephalomyelitis
3. Genetic models for CNS inflammation
4. Some misconceptions about understanding autoimmunity through experiments with knockouts
5. Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein
6. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease
7. Late complications of immune deviation therapy in a nonhuman primate
8. The ups and downs of multiple sclerosis therapeutics
9. Immunotherapy of multiple sclerosis: Where are we? Where should we go?
10. In vivo expression of major histocompatibility complex molecules on oligodendrocytes and neurons during viral infection
11. MHC class I-restricted lysis of human oligodendrocytes by myelin basic protein peptide-specific CD8 T lymphocytes
12. MHC class I-restricted killing of neurons by virus-specific CD8+ T lymphocytes is effected through the Fas/FasL, but not the perforin pathway
13. Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes
14. Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction
15. + T cells in the cerebrospinal fluid from multiple sclerosis patients
16. Myelin-specific CD8 T cells in the pathogenesis of experimental allergic encephalitis and multiple sclerosis
17. Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice
18. A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis
19. B cells and antibodies in CNS demyelinating disease
20. The role of B cells and autoantibodies in multiple sclerosis
21. Molecular immunologic strategies to identify antigens and B-cell responses unique to multiple sclerosis
22. The immunoglobulin G heavy chain repertoire in multiple sclerosis plaques is distinct from the heavy chain repertoire in peripheral blood lymphocytes
23. Antigen discovery in chronic human inflammatory central nervous system disease: Panning phage-displayed antigen libraries identifies the targets of central nervous system-derived IgG in subacute sclerosing panencephalitis
24. Anti-DNA antibodies are a major component of the intrathecal B cell response in multiple sclerosis
25. T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis
26. Immunoglobulin abnormalities in multiple sclerosis. Relation to clinical parameters: Exacerbations and remissions
27. Patterns of cerebrospinal fluid pathology correlate with disease progression in multiple sclerosis
28. The CD1 system: Antigen-presenting molecules for T cell recognition of lipids and glycolipids
29. Decreases in interleukin-4 secretion by invariant CD4(-) CD8(-)V alpha 24J alpha Q T cells in peripheral blood of patients with relapsing-remitting multiple sclerosis
30. Differential expression of NK T cell V alpha 24J alpha Q invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy
31. Costimulation-dependent modulation of experimental autoimmune encephalomyelitis by ligand stimulation of V alpha 14 NK T cells
32. Regulation of experimental autoimmune encephalomyelitis in the C57BL/6J mouse by NK1.1+, DX5+, alpha beta+ T cells
33. A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells
34. Activation of natural killer T cells potentiates or prevents experimental autoimmune encephalomyelitis
35. Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis
36. Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
37. Multiple sclerosis: Recent developments in neuropathology, pathogenesis, magnetic resonance imaging studies and treatment
38. A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions
39. The adhesion molecule and cytokine profile of multiple sclerosis lesions
40. Transcriptional analysis of multiple sclerosis brain lesions reveals a complex pattern of cytokine expression
41. Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays
42. Microarray analysis of gene expression in multiple sclerosis and EAE identifies 5-lipoxygenase as a component of inflammatory lesions
43. Gene expression profiling of the nervous system in murine experimental autoimmune encephalomyelitis
44. Complex immunomodulatory effects of interferon-beta in multiple sclerosis include the upregulation of T helper 1-associated marker genes
45. The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease
46. New approaches to dissect degeneracy and specificity in T cell antigen recognition
47. T cell epitopes of human myelin oligodendrocyte glycoprotein identified in HLA-DR4 (DRB1040*1) transgenic mice are encephalitogenic and are presented by human B cells
48. A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor