Hereditary cancer: Family history, diagnosis, molecular genetics, ecogenetics, and management strategies

Biochimie

Volumn 84, Issue 1, 2002, Pages 3-17

  Lynch, Henry T ^a   Lynch, Jane F ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Genotypic and phenotypic heterogeneity; Hereditary cancer; Molecular genetics

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO;

BREAST CANCER; CANCER CLASSIFICATION; CANCER DIAGNOSIS; CANCER PREVENTION; CANCER SURGERY; CHEMOPROPHYLAXIS; CLINICAL FEATURE; CLINICAL TRIAL; COLORECTAL CANCER; DISEASE MODEL; FAMILIAL CANCER; FAMILIAL COLON POLYPOSIS; FAMILY HISTORY; GASTRECTOMY; GENE MUTATION; GENETIC COUNSELING; GENETIC HETEROGENEITY; GENOTYPE; HIGH RISK PATIENT; HUMAN; LUNG CANCER; MEDICAL LITERATURE; MEDICAL SPECIALIST; MICROSATELLITE INSTABILITY; MOLECULAR GENETICS; NONHUMAN; PHENOTYPE; REVIEW; STOMACH CANCER;

EID: 0036256488     PISSN: 03009084     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-9084(01)01363-3     Document Type: Article

References (134)

1. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
2. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
3. The Human Genome Project: Revealing the shared inheritance of all mankind
4. The incidence of cancer in various strains of mice
5. Genetic factors in the etiology of cancer
6. Effects of genes located on chromosomes III, V, VII, IX, and XIV on the occurrence of pulmonary tumors in the mouse
7. 1 hosts
8. Genetics and smoking-associated cancers. A study of 485 families
9. Familial mesothelioma: Review and family study
10. Host factors in human lung tumors: An example of ecogenetics in oncology
11. DNA copy number changes in familial malignant mesothelioma
12. Ecogenetics of familial pancreatic cancer
13. Ecogenetic origins of cancer in the young: Environmental and genetic determinants
14. Lung tumors following intraperitoneal injection of 1:2:5:6-dibenzanthracene into young mice of three strains
15. Familial aggregations of lung cancer in humans
16. Heritage of colonic polyps
17. An investigation of familial aspects of carcinoma of the prostate
18. Inheritance of cancer of stomach and large intestine in man
19. Hereditary factors in cancer: Study of two large Midwestern kindreds
20. Familial association of carcinoma of the breast and ovary
21. Genetic factors in breast cancer: A survey
22. Genetic heterogeneity and familial carcinoma of the breast
23. Tumor variation in families with breast cancer
24. Early age of onset in familial breast cancer: Genetic and cancer control implications
25. Familial risk and cancer control
26. Linkage of early-onset breast cancer to chromosome 17q21
27. Familial breast-ovarian cancer locus on chromosome 17q12-q23
28. Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study
29. Differential diagnosis of the cancer family syndrome
30. Cancer family 'G' revisited: 1895-1970
31. The cancer family syndrome and cancer control
32. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
33. Identification of the breast cancer susceptibility gene BRCA2
34. Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families
35. Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease
36. Allele increasing susceptibility to human breast cancer may be linked to the glutamate-pyruvate transaminase locus
37. HLA in breast cancer-prone families and the cancer family syndrome
38. Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13
39. A breast-ovarian cancer susceptibility gene maps to chromosome 17q21
40. The potential use of tumor registry data in the recognition and prevention of hereditary and familial cancer
41. Cancer and the family history trail
42. Attenuated familial adenomatous polyposis (AFAP): A phenotypically and genotypically distinctive variant of FAP
43. Genetics and gynecological cancer
44. Genetic susceptibility to nonpolyposis colorectal cancer
45. The tumor spectrum in HNPCC
46. Colorectal carcinoma survival among hereditary nonpolyposis colorectal cancer family members
47. Pathology of hereditary nonpolyposis colorectal cancer with clinical and molecular genetic correlations
48. Unique immunohistochemical features of MSI-classified tumors from HNPCC patients
49. Family Information Service and Hereditary Cancer
50. Familial polyposis coli
51. Ueber polypose Vegetationen der gesammten Dickdarmschleimhaut
52. Polyadenoma tractus intestinalis
53. Two cases of disseminated polyps of the rectum
54. Three cases of multiple polypi of the lower bowel occurring in one family
55. Disseminated polypi of the large intestine becoming malignant: Strictures (malignant adenoma) of the rectum and of the splenic flexure of the colon secondary growths in the liver
56. Cancer and heredity
57. AFAP: Variety is the spice of life
58. Gardner syndrome in a man with an interstitial deletion of 5q
59. Localization of the gene for familial adenomatous polyposis on chromosome 5
60. The gene for familial polyposis coli maps to the long arm of chromosome 5
61. Identification and characterization of the familial adenomatous polyposis coli gene
62. The molecular basis of Turcot's syndrome
63. Different expressivity of two adjacent mutations of the APC gene
64. Different expressivity of two adjacent mutations of the APC gene
65. Familial adenomatous polyposis: Desmoid tumours and lack of ophthalmic lesions (CHRPE) associated with APC mutations beyond codon 1444
66. Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients
67. APC gene mutations and extraintestinal phenotype of familial adenomatous polyposis
68. Classification of familial adenomatous polyposis: A diagnostic nightmare
69. Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary polyposis and osteomatosis
70. Surgery, desmoid tumors and familial adenomatous polyposis: Case report and literature review
71. Germline mutations of the gene for bone morphogenetic protein receptor 1A in juvenile polyposis
72. Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis
73. PTEN and inherited hamartoma-cancer syndromes
74. Molecular classification of the inherited hamartoma polyposis syndromes: Clearing the muddied waters
75. The effect of celecoxib, a cyclooxygenase inhibitor, in familial adenomatous polyposis
76. Heredity with reference to carcinoma
77. Risk of cancer death in first-degree relatives of patients with hereditary nonpolyposis cancer syndrome (Lynch Type II): A study of 130 kindreds in the United Kingdom
78. Screening for hereditary nonpolyposis colorectal cancer in New Zealand
79. Screening for hereditary nonpolyposis colorectal cancer: A study of 22 kindreds in the Netherlands
80. Familial aggregation of tumors in the 3-year experience of a population-based colorectal cancer registry
81. Cancer family syndrome of Lynch
82. Cancer family syndrome: Genetic analysis of 22 Finnish kindreds
83. Frequency of hereditary nonpolyposis colorectal carcinoma
84. Familial colonic cancer without antecedent polyposis
85. Genetic mapping of a locus predisposing to human colorectal cancer
86. Genetic mapping of a second locus predisposing to hereditary nonpolyposis colorectal cancer
87. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
88. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
89. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary nonpolyposis colon cancer
90. Mutation of a mutL homolog in hereditary colon cancer
91. Extracolonic cancer in hereditary nonpolyposis colorectal cancer
92. Molecular genetic evidence of the occurrence of breast cancer as an integral tumor in patients with the hereditary nonpolyposis colorectal cancer syndrome
93. Efficient detection of hereditary nonpolyposis colorectal cancer gene carriers by screening for tumor microsatellite instability before germline genetic testing
94. Microsatellite marker analysis in screening for hereditary nonpolyposis colorectal cancer (HNPCC)
95. Microsatellite instability: Impact on cancer progression in proximal and distal colorectal cancer
96. Microsatellite instability: Impact on cancer progression in proximal and distal colorectal cancers
97. Hereditary nonpolyposis colorectal cancer: The syndrome, the genes, and historical perspectives
98. Molecular mechanisms underlying hereditary nonpolyposis colorectal carcinoma
99. DNA mismatch repair and cancer
100. Familial endometrial cancer in female carriers of MSH6 germline mutations
101. MSH6 and MSH3 are rarely involved in genetic predisposition to nonpolypotic colon cancer
102. Atypical HNPCC owing to MSH6 germline mutations: Analysis of a large Dutch pedigree
103. Germline mutation of EXO1 gene in patients with hereditary nonpolyposis colorectal cancer (HNPCC) and atypical HNPCC forms
104. Suspected hereditary nonpolyposis colorectal cancer: International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer (ICG-HNPCC) criteria and results of genetic diagnosis
105. Association of hereditary nonpolyposis colorectal cancer-related tumors displaying low microsatellite instability with MSH6 germline mutations
106. Chemoprevention of spontaneous intestinal adenomas in the ApcMin mouse model by the nonsteroidal anti-inflammatory drug piroxicam
107. Aspirin and the risk of colorectal cancer in women
108. Reduced expression of cyclooxygenase 2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancers
109. E-cadherin germline mutations in familial gastric cancer
110. Identification of germ-line E-cadherin mutations in gastric cancer families of European origin
111. Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer
112. E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer
113. Diffuse type gastric and lobular breast carcinoma in a familial gastric cancer patient with an E-cadherin germline mutation
114. E-cadherin mutation-based genetic counseling and hereditary diffuse gastric carcinoma
115. Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations
116. The power of genetics to target surgical prevention
117. Occult ovarian tumors in women with BRCA1 and BRCA2 mutations undergoing prophylactic oophorectomy
118. Prophylactic mastectomy: Pathologic findings in high-risk patients
119. Genetics in urogenital cancer
120. Familial factors in bladder carcinoma
121. Mortality in patients with familial adenomatous polyposis
122. Medical-legal risks of incident cancers after clearing colonoscopy
123. Evolution of hereditary non-polyposis colorectal cancer
124. Is there a role for prophylactic subtotal colectomy among hereditary nonpolyposis colorectal cancer germline mutation carriers?
125. Insurance adjudication favoring prophylactic surgery in hereditary breast-ovarian cancer syndrome
126. Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer