Mutations in exon 3 of the β-catenin gene are rare in melanoma cell lines

Melanoma Research

Volumn 12, Issue 2, 2002, Pages 183-186

  Pollock, P M ^a   Hayward, N ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

catenin; Melanoma; Mutation

Indexed keywords

BETA CATENIN;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; MELANOMA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BETA CATENIN; CYTOSKELETAL PROTEINS; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; EXONS; HUMANS; MELANOMA; MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN NEOPLASMS; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 0036256209     PISSN: 09608931     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008390-200204000-00013     Document Type: Article

References (20)

1. The control of beta-catenin and TCF during embryonic development and cancer
2. Cadherins and catenins: Role in signal transduction and tumor progression
3. Wnt signalling in mammalian development and cancer
4. Wnt signaling in oncogenesis and embryogenesis - A look outside the nucleus
5. The Yin-Yang of TCF/ beta-catenin signaling
6. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
7. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
8. Stabilization of beta-catenin by genetic defects in melanoma cell lines
9. β-catenin signaling and cancer
10. Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin
11. Beta-catenin is a target for the ubiquitin-proteasome pathway
12. Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma
13. CDKN2A/p16 is inactivated in most melanoma cell lines
14. Beta-catenin mutations in human prostate cancer
15. Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas
16. Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer
17. Activation of the beta-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations
18. Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3
19. Alterations in cadherin and catenin expression during the biological progression of melanocytic tumours
20. β-catenin mutation and expression analysis in ovarian cancer: Exon 3 mutations and nuclear translocation in 16% of endometrioid tumours