Stability of frozen methacholine solutions in unit-dose syringes for bronchoprovocation

Chest

Volumn 121, Issue 5, 2002, Pages 1634-1637

  Asmus, Michael J ^a   Vaughan, Leigh M ^a   Hill, Malcolm R ^a   Chesrown, Sarah E ^a   Hendeles, Leslie ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

Bronchoprovocation; Methacholine; Stability

Indexed keywords

BICARBONATE; DILUENT; METHACHOLINE; METHACHOLINE CHLORIDE; PHENOL; SODIUM CHLORIDE;

ARTICLE; DRUG POTENCY; DRUG STABILITY; FREEZING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; PROVOCATION TEST; SYRINGE; THAWING; TIME;

EID: 0036252632     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.121.5.1634     Document Type: Article

References (9)

1. Guidelines for methacholine and exercise challenge testing-1999
2. Effect of pH on the stability of methacholine chloride in solution
3. Stability of stored methacholine chloride solutions: Clinically useful information
4. Airway responsiveness: Standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults; official statement of the European Respiratory Society
5. Airway responses to sulfuric acid aerosols in asthmatics: An exposure-response relationship
6. The role of titratable acidity in acid aerosol-induced bronchoconstriction
7. Stability of methacholine chloride solutions under different storage conditions over a 9 month period