Hepatocarcinoma cells constitutively expressing adenoviral E1-genes provide a tumor model for intratumoral replication of E1-deficient adenoviruses

Anticancer Research

Volumn 22, Issue 1 A, 2002, Pages 197-201

  Cichon, Guenter ^a   Boeckh Herwig, Susanne ^a   Elezkurtaj, Sefer ^a   Schmidt, Hartmut H ^a   Hofmann, Christian ^a   Arnold, Wolfgang ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Adenovirus; Human alpha 1 antitrypsin; Intratumoral replication; Oncolysis; Tumor marker

Indexed keywords

ALPHA 1 ANTITRYPSIN; GENE PRODUCT; GLYCOPROTEIN E1; ONCOLYTIC VIRUS; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENETIC ENGINEERING; HUMAN; HUMAN CELL; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; TRANSGENE; TUMOR CELL LINE; TUMOR MODEL; VIRUS GENE; VIRUS REPLICATION;

ADENOVIRIDAE; ADENOVIRUS E1 PROTEINS; ALPHA 1-ANTITRYPSIN; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL DIVISION; GENES, VIRAL; HUMANS; LIVER NEOPLASMS; MICE; MICE, SCID; TUMOR CELLS, CULTURED; VIRUS REPLICATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0036249728     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Prostate-specific antigen and early detection of prostate cancer
2. Prostate-specific antigen density
3. Prostate-specific antigen. Its discovery and biochemical characteristics
4. Tumor biology, p53, guardian of Rb
5. The 19-kilodalton adenovirus E 1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha
6. Wild-type p53 mediates apoptosis by E 1A, which is inhibited by E1B
7. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
8. A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer
9. Phase II trial of intratumoral administration of ONYX-01 replication-selective adenovirus, in patients with refractory head and neck cancer
10. Characterization of cells transformed by Ad5/Adl 2 hybrid early region I plasmids
11. Characteristics of a human cell line transformed by DNA from human adenovirus type 5
12. Efficient oncolysis by a replicating adenovirus (ad) in vivo is critically dependent on tumor expression of primary ad receptors