Cellular and biochemical mechanisms of the resistance of human cancer cells to a new anticancer ribo-nucleoside, TAS-106

Japanese Journal of Cancer Research

Volumn 93, Issue 4, 2002, Pages 445-452

  Shimamoto, Yuji ^a   Kazuno, Hiromi ^a   Murakami, Yuko ^a   Azuma, Atsushi ^a   Koizumi, Katsuhisa ^a   Matsuda, Akira ^b   Sasaki, Takuma ^c   Fukushima, Masakazu ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c KANAZAWA UNIVERSITY   (Japan)

Author keywords

Anticancer ribo nucleoside; Cellular membrane transport; Resistance; TAS 106; Uridine cytidine kinase

Indexed keywords

1 (3 C ETHYNYL BETA DEXTRO RIBO PENTOFURANOSYL)URACIL; 1 (3 C ETHYNYL BETA DEXTRO RIBOPENTOFURANOSYL)CYTIDINE; 3' ETHYNYLCYTIDINE; ANTINEOPLASTIC AGENT; CYTIDINE PHOSPHATE; DNA; DNA DIRECTED RNA POLYMERASE; DNA DIRECTED RNA POLYMERASE III; DRUG METABOLITE; FLUOROURACIL; FLUOROURIDINE; GEMCITABINE; NUCLEIC ACID; NUCLEOTIDE; PHOSPHATE; PROTEIN KINASE; RIBONUCLEOSIDE DERIVATIVE; RNA; RNA POLYMERASE; RNA POLYMERASE II; UNCLASSIFIED DRUG; URACIL DERIVATIVE; URIDINE KINASE; URIDINE PHOSPHATE;

ARTICLE; CANCER CELL; CELL MEMBRANE TRANSPORT; CELL METABOLISM; CHEMOSENSITIVITY; COLON CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS RESISTANCE; DNA SYNTHESIS; DRUG STRUCTURE; DRUG TRANSPORT; ENZYME ACTIVITY; FIBROSARCOMA; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA SYNTHESIS;

ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; CELL MEMBRANE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTIDINE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, BIOLOGICAL; MODELS, CHEMICAL; NUCLEOSIDE-PHOSPHATE KINASE; PHOSPHORYLATION; RNA; TIME FACTORS; URIDINE KINASE;

EID: 0036249645     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2002.tb01276.x     Document Type: Article

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