Suppression of human anti-inflammatory plasma cytokines IL-10 and IL-1RA with elevation of proinflammatory cytokine IFN-γ during the isolation of the Antarctic winter

Journal of Allergy and Clinical Immunology

Volumn 109, Issue 5, 2002, Pages 854-857

  Shearer, William T ^a   Lee, Bang Ning ^b   Cron, Stanley G ^a   Rosenblatt, Howard M ^a   Smith, E O’brian ^a   Lugg, Desmond J ^c   Nickolls, Peter M ^c   Sharp, Robert M ^c   Rollings, Karl ^c   Reuben, James M ^b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c AUSTRALIAN ANTARCTIC DIVISION   (Australia)

Author keywords

Antarctic winter over; Effect of space flight; Latent virus infection; Model of isolation; Proinflammatory vs anti inflammatory cytokine balance; T cell activation

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10;

ANTARCTICA; ARTICLE; BLOOD LEVEL; CELLULAR IMMUNITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; INFLAMMATION; LATENT VIRUS INFECTION; NORMAL HUMAN; PRIORITY JOURNAL; SOCIAL ISOLATION; SPACE FLIGHT; T LYMPHOCYTE ACTIVATION; WINTER;

EID: 0036247487     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2002.123873     Document Type: Article

References (10)

1. Cell mediated immunity in Antarctic wintering personnel: 1984-1992
2. Antarctic isolation: Immune and viral studies
3. Soluble TNF-α receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight
4. Proinflammatory cytokines
5. Anti-inflammatory cytokines
6. Antibody responses to bacteriophage φX-174 in human subjects exposed to the Antarctic winter-over model of spaceflight
7. Effect of space flight on cytokine production and other immunologic parameters of rhesus monkeys
8. Perspectives series: Cytokines and the brain. Neural-immune interactors in health and disease
9. Sleep and cytokine-immune functions in medical, psychiatric and primary sleep disorders
10. Epstein-Barr virus reactivation associated with diminished cell-mediated immunity in Antarctic expeditioners