Pharmacodynamic activity and efficacy of linezolid in a rat model of pneumococcal pneumonia

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 5, 2002, Pages 1345-1351

  Gentry Nielsen, Martha J ^a   Olsen, Keith M ^a   Preheim, Laurel C ^a  

^a VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CEFTRIAXONE; LINEZOLID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BACTEREMIA; BLOOD CULTURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EFFICACY; LOBAR PNEUMONIA; LUNG LAVAGE; MALE; MINIMUM INHIBITORY CONCENTRATION; MORTALITY; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT;

ACETAMIDES; ANIMALS; ANTI-BACTERIAL AGENTS; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; HUMANS; MALE; OXAZOLIDINONES; PNEUMONIA, PNEUMOCOCCAL; RATS; RATS, SPRAGUE-DAWLEY; STREPTOCOCCUS PNEUMONIAE;

EID: 0036239725     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.5.1345-1351.2002     Document Type: Article

References (27)

1. Pulmonary disposition of antimicrobial agents: Methodological considerations
2. Community-acquired pneumonia
3. Emergence of drug-resistant pneumococcal infections in the United States
4. The continued emergence of drug-resistant Streptococcus pneumoniae in the United States: An update from the Centers for Disease Control and Prevention's Pneumococcal Sentinel Surveillance System
5. Mechanism of action and in vitro and in vivo activities of S-6123, a new oxazolidinone compound
6. Oxazolidinones: A review
7. Activity of linezolid against Gram-positive cocci possessing genes conferring resistance to protein synthesis inhibitors
8. Models of pneumonia in ethanoltreated rats
9. Failure of intensive care unit' support to influence mortality, from pneumococcal bacteremia
10. High performance liquid chromatography assay of antibiotics
11. Activity of linezolid against multi-resistant Gram-positive bacteria from diverse hospitals in the United Kingdom
12. Pathogenesis of pneumococcal pneumonia
13. Antimicrobial resistance among respiratory isolates of Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae in the United States
14. In-vitro activity of 29 antimicrobial agents against penicillin-resistant and intermediate isolates of Streptococcus pneumoniae
15. In vitro activities of oxazolidinones U-100592 and U-100766 against penicillin-resistant and cephalosporin-resistant strains of Streptococcus pneumoniae
16. Capsular types and outcome of bcteremic pneumococcal disease in the antibiotic era
17. In vitro activities of linezolid against important gram-positive bacterial pathogens, including vancomycin-resistant enterococci
18. Efficacy of linezolid in experimental otitis media
19. Determination of linezolid in plasma by reverse-phase high-performance liquid chromatography
20. Emerging therapies for serious gram-positive bacterial infections: A focus on linezolid
21. Plasma protein binding of ceftriaxone
22. Ethanol feeding does not affect the efficacy or pharmacokinetics of azithromycin, trovafloxacin, or ceftriaxone in a rat model of pneumococcal pneumonia
23. Mechanism of action of oxazolidinones: Effects of linezolid and eperezolid on translation reactions
24. A simple method for collection of blood from the rat foot
25. Antimicrobial resistance of Streptococcus pneumoniae in the United States, 1979-1987
26. Quantification of cells recovered by bronchoalveolar lavage
27. In vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agents