Nitric oxide plays an insignificant role in direct vasodilator effects of calcium channel blockers in healthy humans

Heart and Vessels

Volumn 16, Issue 3, 2002, Pages 105-110

  Nakamura, Motoyuki ^a   Arakawa, Naoshi ^a   Yoshida, Hiroaki ^a   Naganuma, Yujiro ^a   Nagano, Masahide ^a   Hiramori, Katsuhiko ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Blood flow; Calcium channel blocker; Endothelium; Nitric oxide

Indexed keywords

ACETYLCHOLINE; CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; N(G) METHYLARGININE; NICARDIPINE; NIFEDIPINE; NITRIC OXIDE;

ADULT; ARTICLE; BIOAVAILABILITY; BLOOD PRESSURE MEASUREMENT; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; FOREARM BLOOD FLOW; HEART RATE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; VASCULAR ENDOTHELIUM; VASCULAR RESISTANCE; VASODILATATION; VEIN OCCLUSION PLETHYSMOGRAPHY;

ADULT; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; DILTIAZEM; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; FOREARM; HEART RATE; HUMANS; MALE; NICARDIPINE; NIFEDIPINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; PLETHYSMOGRAPHY; VASODILATION; VASODILATOR AGENTS;

EID: 0036237920     PISSN: 09108327     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003800200004     Document Type: Article

References (15)

1. The calcium antagonist nifedipine stimulates endothelial NO release in therapeutical concentrations
2. Actions of 1,4-dihydropyridines in isolated mesenteric vascular beds
3. Nitric oxide (EDRF) enhances the vasorelaxing effect of nitrendipine in various isolated arteries
4. Ion channels and regulation of intracellular calcium in vascular endothelial cells
5. Calcium- and endothelial-mediated vascular smooth muscle relaxation in rabbit aorta
6. Amlodipine releases nitric oxide from canine coronary microvessels: An unexpected mechanism of action of a calcium channel-blocking agent
7. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man
8. G-monomethyl-L-arginine in patients with essential hypertension
9. Effects of nitric oxide inhibition on basal forearm blood flow in patients with nonischemic chronic heart failure
10. Lacidipine restores endothelium-dependent vasodilation in essential hypertensive patients
11. Effect of treatment on flow-dependent vasodilation of the brachial artery in essential hypertension
12. Calcium channel blockade enhances nitric oxide synthase expression by cultured endothelial cells
13. Nifedipine and diltiazem but not verapamil up-regulate endothelial nitric-oxide synthase expression
14. Synergistic antihypertensive effects of nifedipine on endothelium: Concurrent release of NO and scavenging of superoxide
15. Nifedipine improves endothelial function in hypercholesterolemia, independently of an effect on blood pressure or plasma lipids