Detection and characterization of hibernating myocardium

Nuclear Medicine Communications

Volumn 23, Issue 4, 2002, Pages 311-322

  Mari, C ^a   Strauss, W H ^a  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Hibernating myocardium; Ischaemia; Revascularization; Viability

Indexed keywords

ACETIC ACID C 11; DOBUTAMINE; FLUORODEOXYGLUCOSE F 18; INSULIN; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; THALLIUM;

COMPUTER ASSISTED TOMOGRAPHY; CONFERENCE PAPER; CORONARY ARTERY BLOOD FLOW; DIAGNOSTIC PROCEDURE; HEART INFARCTION; HEART MUSCLE CONTRACTILITY; HUMAN; IMAGING; MYOCARDIAL HIBERNATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; QUALITY OF LIFE;

CORONARY ARTERIOSCLEROSIS; FLUORODEOXYGLUCOSE F18; HEART; HEART FUNCTION TESTS; HUMANS; MYOCARDIAL STUNNING; ORGANOPHOSPHORUS COMPOUNDS; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; TECHNETIUM TC 99M SESTAMIBI; THALLIUM RADIOISOTOPES; TOMOGRAPHY, EMISSION-COMPUTED; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; VENTRICULAR DYSFUNCTION, LEFT;

EID: 0036234470     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1097/00006231-200204000-00004     Document Type: Article

References (76)

1. Tennant R, Wiggers CJ. The effect of coronary occlusion on myocardial contractions. Am J Physiol 1935; 112: 351.
2. Braunwald E, Kloner RA. The stunned myocardium: prolonged, postischemic ventricular dysfunction. Circulation 1982; 66: 1146.
3. Rahimtoola SH. The hibernating myocardium. Am Heart J 1989; 117: 211-221.
4. Dispersyn GD, Borgers M, Flameng W. Apoptosis in chronic hibernating myocardium: sleeping to death? Cardiovasc Res 2000; 45(3): 696-703.
5. Shen YT, Vatner SF. Mechanism of impaired myocardial function during progressive coronary stenosis in conscious pigs. Hibernation versus stunning. Circ Res 1995; 76: 479-488.
6. Ito BR. Gradual onset of myocardial ischemia results in reduced myocardial infarction. Association with reduced contractile function and metabolic downregulation. Circulation 1995; 91(7): 2058-2070.
7. St Louis JD, Hughes GC, Kypson AP et al. An experimental model of chronic myocardial hibernation. Ann Thorac Surg 2000; 69(5): 1351-1357.
8. Maes A, Flameng W, Nuyts J et al. Histological alterations in chronically hypoperfused myocardium. Correlation with PET findings. Circulation. 1994; 90(2): 735-745.
9. Vanoverschelde JL, Wijns W, Depre C et al. Mechanisms of chronic regional postischemic dysfunction in humans: new insights from the study of noninfarcted collateral-dependent myocardium. Circulation 1993; 87: 1513-1523.
10. Marinho NV, Keogh BE, Costa DC, Lammerstma AA, Ell PJ, Camici PG. Pathophysiology of chronic left ventricular dysfunction: new insights from the measurement of absolute myocardial blood flow and glucose utilization. Circulation 1996; 93: 737-744.
11. Wilson JM. Reversible congestive heart failure caused by myocardial hibernation. Tex Heart Inst J 1999; 26(1): 19-27.
12. Dispersyn GD, Ausma J, Thone F, et al. Cardiomyocyte remodelling during myocardial hibernation and atrial fibrillation: prelude to apoptosis. Cardiovasc Res. 1999; 43(4): 947-957.
13. Wijns W, Vather SP, Carnici PG. Hibernating myocardium. N Engl J Med 1998; 339: 173-181.
14. Kagiya T, Rocha-Singh KL, Honbo N, Karliner JS. Alpha 1 adrenoceptor mediated signal transduction in neonatal rat ventricular myocytes: effects of prolonged hypoxia and reoxygenation. Cardiovasc Res. 1991; 25(7): 609-616.
15. Elsasser A, Schlepper M, Zimmermann R et al. The extracellular matrix in hibernating myocardium - a significant factor causing structural defects and cardiac dysfunction. Mol Cell Biochem. 1998; 186(1-2): 147-158.
16. Schwarz ER, Schoendube FA, Kostin S et al. Prolonged myocardial hibernation exacerbates cardiomyocytes degeneration and impairs recovery of function after revascularization. J Am Coll Cardiol 1998; 31(5): 1018-1026.
17. Marwick TH, Zuchowski C, Lauer MS. Functional status and quality of life in patients with heart failure undergoing coronary bypass surgery after assessment of myocardial viability. J Am Coll Cardiol. 1999; 33(3): 750-758.
18. Di Carli MF, Asgarzadie F, Schelbert HR et al. Quantitative relation between myocardial viability and improvement in heart failure symptoms after revascularization in patients with ischemic cardiomyopathy. Circulation. 1995 15; 92(12): 3436-3444.
19. Gioia G, Powers J, Iskandrian AS. Prognostic value of redistribution tomographic thallium-201 imaging in ischemic cardiomyopathy. Am J Cardiol 1995; 75: 759-762.
20. DiCarli MF, Davidson M, Little R et al. Value of metabolic imaging with positron emission tomography for evaluating prognosis in patients with coronary artery disease and left ventricular dysfunction. Am J Cardiol 1994; 73: 527-533.
21. Sharir T, Berman DS, Lewin HC et al. Incremental prognostic value of rest-redistribution (201)Tl single-photon emission computed tomography. Circulation 1999; 100(19): 1964-1970.
22. Beanlands RS, Hendry PJ, Masters RG et al. Delay in revascularization is associated with increased mortality rate in patients with severe left ventricular dysfunction and viable myocardium on fluorine 18-fluorodeoxyglucose positron emission tomography imaging. Circulation. 1998 10; 98(19 Suppl): 1151-1156.
23. Birnbaum Y, Kloner RA. Myocardial viability. West J Med 1996; 165(6): 364-371.
24. Schelbert HR, Henze E, Phelps ME, Kuhl DE. Assessment of regional myocardial ischemia by positron-emission computed tomography. Am Heart J 1982; 103(4 Pt 2): 588-597.
25. Tillisch J, Brunken R, Marshall R et al. Reversibility of cardiac wall-motion abnormalities predicted by positron tomography. N Engl J Med 1986; 314(14): 884-888.
26. Eitzman D, Al-Aouar Z, Kanter HL et al. Clinical outcome of patients with advanced coronary artery disease after viability studies with positron emission tomography. J Am Coll Cardiol 1992; 20: 559.
27. Tillisch J, Brunken R, Marshall R et al. Reversibility of cardiac wall-motion abnormalities predicted by positron emission tomography. N Engl. J Med 1986; 314: 884.
28. Tamaki N, Kawamoto M, Tadamura E et al. Prediction of reversible ischemia after revascularization: perfusion and metabolic studies with positron emission tomography. Circulation 1995; 91: 1697.
29. Conversano A, Walsh JF, Geltman EM et al. Delineation of myocardial stunning and hibernation by positron emission tomography in advanced coronary artery disease. Am Heart J 1996; 131: 440.
30. Bax JJ, Patton JA, Poldermans D, Elhendy A, Sandler MP. 18-Fluorodeoxyglucose imaging with positron emission tomography and single photon emission computed tomography: cardiac applications. Semin Nucl Med 2000; 30(4): 281-298.
31. 18F-FDG-PET to optimize recognition of myocardial hibernation. Nucl Med Commun 1998; 19(6): 535-545.
32. Hacker TA, Renstrom B, Nellis SH, Lieddtke AJ. Effect of repetitive stunning on myocardial metabolism in pig hearts. Am J Physiol 1997; 273: H1395-H1402.
33. Di Carli MF, Prcevski P, Singh TP et al. Myocardial Blood flow, function, and metabolism in repetitive stunning. J Nucl Med. 2000; 41(7): 1227-34.
34. Schoder H, Campisi R, Ohtake T et al. Blood flow-metabolism imaging with positron emission tomography in patients with diabetes mellitus for the assessment of reversible left ventricular contractile dysfunction. J Am Coll Cardiol 1999; 33(5): 1328-1337.
35. Rozanski A, Bernard D, Gray R et al. Use of thallium-201 redistribution scintigraphy in the preoperative differentiation of reversible myocardial asynergy. Circulation 1981; 64: 936-944.
36. Hendel RC. Single-photon perfusion imaging for the assessment of myocardial viability. J Nucl Med 1994; 35(4 Suppl): 23S-31S.
37. Chiba H, Kusuoka H, Ohno J, Nishimura T. Glucose-loading thallium-201 myocardial SPECT. J Nucl Med 1997; 38(4): 573-577.
38. Budinger TF, Pohost GM. Thallium ‘redistribution’. An explanation. J Nucl Med 1986; 27: 996 (abstr.).
39. Budinger TF, Knittel BL. Cardiac thallium redistribution and model. J Nucl Med 1987; 28: 588.
40. Kayden DS, Sigal SL, Soufer R et al. 24-hour planar thallium-201 delayed imaging: is reinjection necessary? Circulation 1989; 80: II-376 (abstr. suppl 2).
41. Ohtani H, Tamaki N, Yonekura Y et al. Value of thallium-201 reinjection after delayed SPECT imaging for predicting reversible ischemia after coronary artery bypass grafting. Am J Cardiol 1990; 66: 394-399.
42. Rocco TP, Dilsizian V, McKusick KA et al. Comparison of thallium redistribution with rest ‘reinjection’ imaging for detection of viable myocardium. Am J Cardiol 1990; 66: 158-163.
43. Tamaki N, Ohtani H, Yonekura Y et al. Significance of fill-in after thallium-201 reinjection following delayed imaging: comparison with regional wall motion and angiographic findings. J Nucl Med 1990; 31: 1617-1623.
44. Tillisch JH, Brumken R, Marshall R et al. Reversibility of cardiac wall-motion abnormalities predicted by positron tomography. N Engl J Med 1986; 314: 884-888.
45. Tamaki N, Yonekura Y, Yamashita K et al. Positron emission tomography using fluorine-18 deoxyglucose in evaluation of coronary artery bypass grafting. Am J Cardiol 1989; 64: 860-865.
46. t18F-fluorodeoxyglucose. Circulation 1991; 83: 26-37.
47. Bonow RO, Dilsiazian V. Thallium 201 for assessment of myocardial viability. Semin Nucl Med 1991; 21: 230-241.
48. Schafers M, Matheja P, Hasfeld M et al. The clinical impact of thallium-201 reinjection for the detection of myocardial hibernation. Eur J Nucl Med 1996; 23(4): 407-413.
49. Qureshi U, Nagueh SF, Afridi I et al. Dobutamine echocardiography and quantitative rest-redistribution 201Tl tomography in myocardial hibernation. Relation of contractile reserve to 201Tl uptake and comparative prediction of recovery of function. Circulation. 1997 4; 95(3): 626-635.
50. Piwnica-Worms D, Kronauge JF, Chiu ML. Uptake and retention of hexakis (2-methoxyisobutylisonitrile) technetium (I) in cultured chick myocardial cells. Mitochondrial and plasma membrane potential dependence. Circulation 1990; 82: 1826-1838.
51. Beanlands RS, Dawood F, Wen WH et al. Are the kinetics of technetium-99m methoxyisobutyl isonitrile affected by cell metabolism and viability? Circulation 1990; 82: 1802-1814.
52. Okada RD, Glover D, Gaffney T, Williams S. Myocardial kinetics of technetium-99m-hexakis-2-methoxy-2-methylpropyl-isonitrile. Circulation 1988; 77: 491-498.
53. Wackers FJ, Berman DS, Maddahi J et al. Technetium-99m hexakis 2-methoxyisobutylisonitrile: human biodistribution, dosimetry, safety, and preliminary comparison to thallium-201 for myocardial perfusion imaging. J Nucl Med 1989; 30: 301-311.
54. 99mTc-2-methoxyisobutylisonitrile: a direct comparison in normal individuals and patients with coronary artery disease. Circulation 1989; 79: 1282-1293.
55. Cuocolo A, Pace L, Ricciardelli B et al. Identification of viable myocardium in patients with chronic coronary artery disease: comparison of thallium-201 scintigraphy with reinjection and technetium-99m-methoxyisobutyl isonitrile. J Nucl Med. 1992; 33(4): 505-511.
56. Maurea S, Cuocolo A, Pace L et al. Left ventricular dysfunction in coronary artery disease: comparison between rest-redistribution thallium 201 and resting technetium 99m methoxyisobutyl isonitrile cardiac imaging. J Nucl Cardiol. 1994; 1(1): 65-71.
57. Marzullo P, Sambuceti G, Parodi O. The role of sestamibi scintigraphy in the radioisotopic assessment of myocardial viability. J Nucl Med 1992; 33: 1925-1930.
58. 18Ffluorodeoxyglucose. Circulation 1994; 89: 578-587.
59. Sciagra R, Bisi G, Santoro GM, Agnolucci M, Zoccarato O, Fazzini PF. Influence of the assessment of defect severity and intravenous nitrate administration during tracer injection on the detection of viable hibernating myocardium with data-based quantitative technetium-99m-labeled sestamibi single photon emission computed tomography. J Nucl Cardiol 1996; 3: 221-230.
60. 201Thallium and Tc99m-sestamibi. Circulation 1994; 89: 2552-2561.
61. Maes AF, Borgers M, Flameng W et al. Assessment of myocardial viability in chronic coronary artery disease using technetium-99m sestamibi SPECT. Correlation with histologic and positron emission tomographic studies and functional follow-up. J Am Coll Cardiol 1997; 29: 62-68.
62. Soufer R, Dey HM, Ng CK, Zaret BL. Comparison of sestamibi single-photon emission computed tomography with positron emission tomography for stimulating left ventricular myocardial viability. Am J Cardiol 1995; 75: 1214-1219.
63. Maublant JC, Marcaggi X, Lusson JR et al. Comparison between thallium-201 and technetium-99m methoxyisobutyl isonitrile defect size in single-photon emission computed tomography at rest, exercise and redistribution in coronary artery disease. Am J Cardiol. 1992 15; 69(3): 183-187.
64. Sansoy V, Glover D, Watson DD et al. Comparison of thallium-201 resting redistribution with technetium-Tc99m-sestamibi uptake and functional response to dobutamine for assessment of myocardial viability. Circulation 1995; 92: 994-1004.
65. 201Tl imaging and coronary angiography in a phase III multicenter trial. Tetrofosmin International Trial Study Group. Circulation 1995; 91: 313-319.
66. Matsunari I, Fujino S, Taki J et al. Quantitative rest technetium-99m tetrofosmin imaging in predicting functional recovery after revascularization: comparison with rest-redistribution thallium-201. J Am Coll Cardiol 1997; 29(6): 1226-1233.
67. Galassi AR, Tamburino C, Grassi R et al. Comparison of technetium 99m-tetrofosmin and thallium-201 single photon emission computed tomographic imaging for the assessment of viable myocardium in patients with left ventricular dysfunction. J Nucl Cardiol 1998; 5(1): 56-63.
68. 18F-fluorodeoxyglucose. J Am Coll Cardiol 1998; 32(4): 927-935.
69. 18F-FDG PET). Ann Nucl Med 1999; 13(3): 135-140.
70. Menna F, Acampa W, Florimonte L et al. Cardiac tomography with 99mTc-tetrofosmin after nitrate administration in patients with ischemic cardiopathy and left ventricular dysfunction. Radiol Med (Torino) 2000; 99(4): 258-263.
71. Opie LH. The heart physiology, from cell to circulation. 3rd edition. Lippincott-Raven publishers. Philadelphia. New York, 1998. Chapter 19, pages 563-588.
72. Braunwald E. Heart disease: a textbook of cardiovascular medicine, 1992. 4th edition. WB Saunders Company. Philadelphia. ch. 12, p. 388.
73. Braunwald E. Heart disease: a textbook of cardiovascular medicine, 1992. 4th edition. WB Saunders Company. Philadelphia. ch. 38, p. 1328.
74. Johnson LL. Thallium-201 to assess myocardial viability. In: Iskandrian AS, van der Wall EE, eds. Myocardial viability. Dordrecht, The Netherlands: Kluwer, 1994, 19-37.
75. Opie LH. The Heart Physiology, from Cell to Circulation. 3rd edition. Lippincott-Raven publishers. Philadelphia. New York, 1998. Chapter 19, pp 563-588.
76. Gould KL. Coronary Artery Stenosis. Amsterdam: Elsevier, 1991. Chapter 7, pp 79-91.