'Real world' pragmatic clinical trials: What are they and what do they tell us?

Pediatric Allergy and Immunology

Volumn 13, Issue 1, 2002, Pages 4-9

  Helms, Peter J ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Asthma; Child; Clinical trials; Licensing; Medical review

Indexed keywords

CORTICOSTEROID; CROMOGLYCATE DISODIUM;

ASTHMA; ATOPY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; COST BENEFIT ANALYSIS; DRUG EFFECT; EVIDENCE BASED MEDICINE; FORCED EXPIRATORY VOLUME; LICENSING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW;

ANTI-INFLAMMATORY AGENTS; ASTHMA; CHILD; CONTROLLED CLINICAL TRIALS; HUMANS; PRACTICE GUIDELINES;

EID: 0036234159     PISSN: 09056157     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3038.2002.00194.x     Document Type: Review

References (43)

1. Efficacy and safety of inhaled steroid and cromone treatment in school-age children: A randomized pragmatic pilot study
2. The British guidelines on asthma management: 1995 Review and position statement
3. Third international pediatric consensus statement on the management of childhood asthma
4. Review of prescribed treatment for children with asthma in 1990
5. Asthma medication in children - 1991
6. Decrease in hospitalization for treatment of childhood asthma with increased use of antiinflammatory treatment, despite an increase in prevalence of asthma
7. Societal and health care benefits of early use of inhaled steroids
8. Inflammation and airway function in asthma: Wat you see is not necessarily what you get
9. Airway mucosal inflammation even in patients with newly diagnosed asthma
10. Measuring compliance with inhaled medication in asthma
11. Compliance with inhaled asthma medication in preschool children
12. Comparison of patients' compliance with prescribed oral and inhaled asthma medications
13. Pragmatic versus explanatory trials
14. What are the pragmatic trials?
15. The pragmatic approach to stroke trial design: Stroke register, pilot trial, assessment of neurological then functional outcome
16. Is bleeding time measurement useful for choosing the liver biopsy route? The results of a pragmatic, prospective multicentric study in 219 patients
17. Octreotide compared with placebo in a treatment strategy for early rebleeding in cirrhosis. A double blind, randomized pragmatic trial
18. Pragmatic randomised controlled trial of local corticosteroid injection and naproxen for treatment of lateral epidondylitis of elbow in primary care
19. Open access follow-up for inflammatory bowel disease: Pragmatic randomised trial and cost effectiveness study
20. Paediatric asthma. 'Real world' measures of effectiveness
21. Long-term effects of budesonide or nedocromil in children with asthma
22. Early introduction of inhaled steroids in wheezing children presenting in primary care. A pilot study
23. Licensing of medicines
24. Unlicensed and off label drug use in paediatric wards: Prospective study
25. Off label and unlicensed drug use among French office based paediatricians
26. Unlicensed and off label drug use in neonates
27. Unlicensed and off label drug use in general practice
28. Status of drug approval processes and regulation of medications for children
29. Efficacy and safety of high-dose inhaled steroids in children with asthma: A comparison of fluticasone propionate with budesonide
30. Relative safety and efficacy of inhaled corticosteroids
31. Comparison of the efficacy and safety of inhaled fluticasone propionate 200 micrograms/day with inhaled beclomethasone dipropionate 400 micrograms/day in mild and moderate asthma
32. Urine cortisol excretion in children treated with high doses of inhaled corticosteroids: A comparison of budesonide and beclomethasone
33. A comparison of inhaled budesonide and beclomethasone dipropionate in childhood asthma
34. Asthma treatment with a new corticosteroid aerosol, budesonide, administered twice daily by spacer inhaler
35. Disodium cromoglycate (FPL 670) ('Intal'): A specific inhibition of reaginic antibody-antigen mechanisms
36. Inhaled sodium cromoglycate as maintenance therapy in children with asthma
37. Inhaled disodium cromoglycate as maintenance therapy for childhood asthma: Time to consign to history?
38. Long-acting beta(2)-agonists in management of childhood asthma: A critical review of the literature
39. Addition of salmeterol versus doubling the dose of beclomethasone in children with asthma