Direct demonstration of the productive capability of cytokines at the single cell level in lung sarcoidosis using multicolor cytometry

Respiration

Volumn 69, Issue 2, 2002, Pages 155-164

  Kunisawa, Akira ^a   Kawanishi, Yoshikazu ^a   Tago, Hidekazu ^a   Nagate, Akira ^a   Kasuga, Ikuma ^a   Ohyashiki, Kazuma ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Flow cytometry; Sarcoidosis; T cells

Indexed keywords

BREFELDIN A; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE;

ADULT; AGED; ARTICLE; CELL COUNT; CELL STIMULATION; CELL STRUCTURE; CLINICAL ARTICLE; COLOR; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOMETRY; FEMALE; HUMAN; LUNG LAVAGE; LUNG SARCOIDOSIS; LYMPHOCYTOPOIESIS; MALE; PRIORITY JOURNAL; PROTEIN ANALYSIS; T LYMPHOCYTE;

ADULT; ANTIGENS, CD4; ANTIGENS, CD8; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; FEMALE; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-4; MALE; MIDDLE AGED; SARCOIDOSIS, PULMONARY; T-LYMPHOCYTE SUBSETS;

EID: 0036230342     PISSN: 00257931     EISSN: None     Source Type: Journal    
DOI: 10.1159/000056319     Document Type: Article

References (47)

1. Comparison of bronchoalveolar lavage helper/suppressor T-cell ratios in sarcoidosis versus other interstitial lung diseases
2. Pulmonary sarcoidosis: A disorder mediated by excess helper-T-lymphocyte activity sites of disease activity
3. Preferential messenger RNA expression of Th1-type cells (IFN-gamma+, IL-2+) in classical delayed-type (tuberculin) hypersensitivity reactions in human skin
4. Defining protective responses to pathogens: Cytokine profiles in leprosy lesions
5. Gamma interferon is spontaneously released by alveolar macrophages and lung T lymphocytes in patients with pulmonary sarcoidosis
6. Spontaneous release of interleukin-2 by lung T-lymphocytes in active pulmonary sarcoidosis
7. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
8. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
9. H1 clones
10. Divergent T-cell cytokine patterns in inflammatory arthritis
11. Activated T cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia
12. sVCAM-1 level after segmental antigen challenge correlate with eosinophil influx, IL-4 and IL-5 production, and the late phase response
13. Phenotype of cells expressing mRNA for TH2-type (interleukin-4 and interleukin-5) and TH1-type (interleukin-2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects
14. Reduced interferon-gamma (IFN-gamma) secretion with increased IFN-gamma mRNA expression in atopic dermatitis: Evidence for a post-transcriptional defect
15. Pulmonary sarcoidosis: Patients of cytokine release in vitro
16. Clonal analysis of lung and blood T cells in patients with sarcoidosis
17. Detection of intracellular cytokines by flow cytometry
18. Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry
19. The isolation and characterization of the human helper inducer T cell subset
20. Brefeldin A. Insights into the control of membrane traffic and organelle structure
21. Internalization, lysosomal degradation and new synthesis of surface membrane CD4 in phorbol ester-activated T-lymphocytes and U-937 cells
22. Regulation of CD4 and CD8 expression on mouse T cells. Active removal from the cell surface by two mechanisms
23. Interstitial lung diseases
24. Lung-restricted activation of the alveolar macrophage/monocyte system in pulmonary sarcoidosis
25. Recombinant interferon-γ increases HLA-DR synthesis and expression
26. Characterization of the gamma-interferon-mediated induction of antigen-presenting ability in P388D1 cells
27. Activation of human monocyte cytotoxicity by natural and recombinant immune interferon
28. Killing intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes. Evidence that interferon-gamma is the activating lymphokine
29. Evidence for a Th1-like bronchoalveolar T-cell subset and predominance of interferon-gamma gene activation in pulmonary tuberculosis
30. The role of IFN-gamma in delayed-type hypersensitivity mediated by Th1 clones
31. Purified human interleukin-2 enhances induction of immune interferon
32. Interleukin 2-mediated immune interferon (IFN-gamma) production by human T cells and T cell subsets
33. Restricted production of interleukin 4 by actived human T cells
34. Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis
35. Enhanced mRNA expression of Th1 cytokines and IL-12 in active pulmonary sarcoidosis
36. Increased levels of interleukin-18 in patients with pulmonary sarcoidosis
37. The value of interleukin-12 as an activity marker of pulmonary sarcoidosis
38. Cytokine mRNA gene expression in active and nonactive pulmonary sarcoidosis
39. Th1 cytokine pattern in sarcoidosis is expressed by bronchoalveolar CD4+ and CD8+ T cells
40. Analysis of intracellular cytokines in CD4+ and CD8+ lung and blood T cells in sarcoidosis
41. Pulmonary sarcoidosis: A disorder mediated by excess helper T-lymphocyte activity at sites of disease activity
42. Role of IL-4 and IFN-gamma in Schistosoma mansoni egg-induced hypersensitivity granuloma formation. Orchestration, relative contribution, and relationship to macrophage function
43. Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni
44. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
45. Th1 and Th2 responses regulate experimental lung granuloma development
46. Th1/Th2 cell distribution in pulmonary sarcoidosis
47. T cell activation-induced epitopes of the house dust mite allergen Der p I. Proliferation and lymphokine production patterns by Der p I-specific CD4+ T cell clones