Pharmacokinetics and cell trafficking dynamics of 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride (FTY720) in cynomolgus monkeys after single oral and intravenous doses

Journal of Pharmacology and Experimental Therapeutics

Volumn 301, Issue 2, 2002, Pages 519-526

  Li, Hongshan ^a,b,c   Meno Tetang, Guy M L ^a,b,c   Chiba, Kenji ^a,b,c   Arima, Noriyuki ^a,b,c   Heining, Peter ^a,b,c   Jusko, William J ^a,b,c  

^a UNIVERSITY AT BUFFALO   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c Yoshitomi Pharmaceutical Industries Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD2 ANTIGEN; CD20 ANTIGEN; FINGOLIMOD; IMMUNOSUPPRESSIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; B LYMPHOCYTE; BLOOD VOLUME; BOLUS INJECTION; CELL TRANSPORT; COMPARTMENT MODEL; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFECT; DRUG HALF LIFE; FEMALE; GRAFT REJECTION; IC 50; LYMPHOCYTE COUNT; MALE; MONKEY; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; SEX DIFFERENCE; T LYMPHOCYTE; TIME SERIES ANALYSIS;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL TRANSPORT; FEMALE; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRAVENOUS; MACACA FASCICULARIS; MALE; MODELS, ANIMAL; PROPYLENE GLYCOLS; SEX FACTORS; SPHINGOSINE;

EID: 0036229965     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.301.2.519     Document Type: Article

References (32)

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7. Physiological parameters in laboratory animals and humans
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