Lack of mutagenicity of a red food colour impurity (1-carboxyl-5,7-dibromo-6-hydroxy-2,3,4-trichloroxanthone) in Phloxine B

Food Additives and Contaminants

Volumn 19, Issue 4, 2002, Pages 350-356

  Aoki, H ^a   Ogawa, Y ^a   Yukawa, C ^a   Nakamura, M ^a   Nakazawa, H ^a  

^a SAN EI GEN F F I INC   (Japan)

Author keywords

1 carboxyl 5,7 dibromo 6 hydroxy 2,3,4 trichloroxanthone (HXCA); Mutagenicity test; pH zone refining counter current chromatography; Phloxine B

Indexed keywords

1 CARBOXYL 5,7 DIBROMO 6 HYDROXY 2,3,4 TRICHLOROXANTHONE; FOOD DYE; MUTAGENIC AGENT; PHLOXINE; UNCLASSIFIED DRUG;

AMES TEST; ARTICLE; CONTROLLED STUDY; COUNTER CURRENT CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MUTAGENICITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PRIORITY JOURNAL; REFERENCE VALUE; ULTRAVIOLET SPECTROSCOPY;

CHROMATOGRAPHY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EOSINE I BLUISH; FOOD COLORING AGENTS; FOOD CONTAMINATION; HUMANS; MUTAGENICITY TESTS; XANTHENES; XANTHONES;

EID: 0036228864     PISSN: 0265203X     EISSN: None     Source Type: Journal    
DOI: 10.1080/02652030110088851     Document Type: Article

References (11)

1. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test
2. pH-peak-focusing and pH-zone-refining counter-current chromatography
3. pH-zone-refining counter-current chromatography
4. pH-zone-refining counter-current chromatography
5. In vitro host-mediated 'rec-assay' procedure for screening chemical mutagens; and phloxine, a mutagenic red dye detected
6. Thin layer chromatography of synthetic dyes (VIII). On the decomposition products of xanthene dyes (3). Tetrachlorofluorescein and phloxine
7. Absence of mutagenicity of phloxine and phloxine B in Escherichia coli and in Salmonella typhimurium
8. Analysis of 1-carboxy-5,7-dibromo-6-hydroxy-2,3,4-trichloroxanthone in the color additives D and C Red Nos. 27 and 28 (phloxine B) by liquid chromatography
9. Preparative separation of components of the color additive D&C Red No. 28 (phloxine B) by pH-zone-refining counter-current chromatography
10. A new preparative-scale purification technique: pH-zone-refining counter-current chromatography