Evidence for the mechanism of the irreversible inhibition of oestrone sulphatase (ES) by aminosulphonate based compounds

Journal of Steroid Biochemistry and Molecular Biology

Volumn 80, Issue 4-5, 2002, Pages 429-440

  Ahmed, Sabbir ^a   Owen, Caroline P ^a   James, Karen ^b   Patel, Chirag K ^a   Sampson, Luther ^c  

^a KINGSTON UNIVERSITY   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Aminosulphamate; Inhibitors; Mechanism; Oestrone; Sulphatase

Indexed keywords

2,2 DICHLOROETHYLMETHANESULFONATE; 2,2,2 TRICHLOROETHYLMETHANESULFONATE; 2,2,2 TRICHLOROETHYLSULFAMATE; 2,2,2 TRIFLUOROETHYLMETHANESULFONATE; 3 METHYLPHENYLSULFAMATE; 4 FLUOROPHENYLSULFAMATE; 4 METHYLPHENYLSULFAMATE; DECYL O AMINOSULFONATE; DECYLMETHANESULFONATE; DODECYL O AMINOSULFONATE; DODECYLMETHANESULFONATE; ENZYME INHIBITOR; ESTRONE SULFATASE; HEPTYL O AMINOSULFONATE; HEPTYLMETHANESULFONATE; MESYLIC ACID BUTYL ESTER; MESYLIC ACID ETHYL ESTER; NONYL O AMINOSULFONATE; NONYLMETHANESULFONATE; OCTYL O AMINOSULFONATE; OCTYLMETHANESULFONATE; PHENYLSULFAMATE; PROPYLMETHANESULFONATE; SULFATASE; SULFONIC ACID DERIVATIVE; TRIDECYL O AMINOSULFONATE; TRIDECYLMETHANESULFONATE; UNCLASSIFIED DRUG; UNDECYL O AMINOSULFONATE; UNDECYLMETHANESULFONATE; UNINDEXED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

ANIONS; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; STRUCTURE-ACTIVITY RELATIONSHIP; SULFANILIC ACIDS; SULFATASES; SULFONIC ACIDS; TIME FACTORS; WATER;

EID: 0036228803     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(02)00036-5     Document Type: Article

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