Improvement in the resting-cell bioconversion of penicillin G to deacetoxycephalosporin G by addition of catalase

Letters in Applied Microbiology

Volumn 34, Issue 4, 2002, Pages 290-292

  Gao, Q ^a   Demain, A L ^a  

^a DREW UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCONVERSION; DRUG PRODUCTS; REACTION INTERMEDIATES;

'CURRENT; CO FACTORS; ENZYME INACTIVATION; PENICILLIN G; RESTING CELLS; RING-EXPANSION REACTION; STREPTOMYCES CLAVULIGERUS; SUPER OXIDE DISMUTASE; SUPEROXIDE DISMUTASES; SUPEROXIDE PRODUCTION;

ENZYMES;

CATALASE; CEPHALOSPORIN DERIVATIVE; DEACETOXYCEPHALOSPORIN G; HYDROGEN PEROXIDE; PENICILLIN G; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ENZYME;

ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; CYCLOADDITION; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME MECHANISM; ENZYME SYNTHESIS; STREPTOMYCES CLAVULIGERUS;

ACTINOBACTERIA (CLASS); STREPTOMYCES; STREPTOMYCES CLAVULIGERUS; UNCULTURED ACTINOMYCETE;

EID: 0036228294     PISSN: 02668254     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1472-765x.2002.01084.x     Document Type: Article

References (11)

1. Inactivation of deacetoxycephalosporin C synthase in extracts of Streptomyces clavuligerus during bioconversion of penicillin G to deacetoxycephalosporin G
2. Further studies on the bioconversion of penicillin G into deacetoxycephalosporin G by resting cells of Streptomyces clavuligerus NP1
3. Chemistry of cephalosporin antibiotics. 21. Conversion of penicillins to cephalosporins
4. Elucidation of conditions allowing conversion of penicillin G and other penicillins to deacetoxycephalosporins by resting cells and extracts of Streptomyces clavuligerus NP1
5. Stimulatory effect of growth in the presence of alcohols on biotransformation of penicillin G into cephalosporin-type antibiotics by resting cells of Streptomyces clavuligerus NP1
6. Improvement in the bioconversion of penicillin G to deacetoxycephalosporin G by elimination of agitation and addition of decane
7. Effect of solvents on bioconversion of penicillin G to deacetoxycephalosporin G
8. Cephalosporin production by cell free extracts from Streptomyces clavuligerus
9. Conversion of isopenicillin N to cephalosporin(s) by cell-free extracts of Cephalosporium acremonium
10. In vivo conversion of penicillin N into a cephalosporin type antibiotic by a non-producing mutant of Streptomyces clavuligerus
11. Desacetoxycephalosporin C synthetase: Importance of order of cofactor/reactant addition